ChemicalBook > CAS DataBase List > D-Glucosamine hydrochloride

D-Glucosamine hydrochloride

Product Name
D-Glucosamine hydrochloride
CAS No.
66-84-2
Chemical Name
D-Glucosamine hydrochloride
Synonyms
GLUCOSAMINE HYDROCHLORIDE;GLUCOSAMINE HCL;D-GLUCOSAMINE HCL;D-Glucosamine Salt;Glucosamine for system suitability CRS;2-amino-2-deoxy-D-glucose hydrochloride (1:1);cosamin;NSC 758;D-GLCN HCL;NSC 234443
CBNumber
CB2181059
Molecular Formula
C6H14ClNO5
Formula Weight
215.63
MOL File
66-84-2.mol
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D-Glucosamine hydrochloride Property

Melting point:
190-194 °C (dec.)(lit.)
alpha 
72.5 º (c=2, H2O, 5hrs.)
refractive index 
72 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
crystalline
color 
White
biological source
Aspergillus niger
maize fruit
Water Solubility 
soluble
Merck 
14,4458
BRN 
4157370
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
InChI
InChI=1/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4-,5-,6?;/s3
InChIKey
QKPLRMLTKYXDST-LPRXMDNASA-N
SMILES
[C@H]1(CO)OC([C@H](N)[C@@H](O)[C@@H]1O)O.Cl |&1:0,5,7,9,r|
LogP
-2.375 (est)
CAS DataBase Reference
66-84-2(CAS DataBase Reference)
EPA Substance Registry System
D-Glucose, 2-amino-2-deoxy-, hydrochloride (66-84-2)
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Safety

Hazard Codes 
F,Xi,Xn
Risk Statements 
21-36/38-46-62-63
Safety Statements 
24/25-53-36/37-26-25
WGK Germany 
2
RTECS 
LZ6665000
F 
3-10
Hazard Note 
Highly Flammable
TSCA 
Yes
HS Code 
29329985
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001406
Product name
Glucosamine hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$225
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001381
Product name
Glucosamine for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
3 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
G1514
Product name
D-(+)-Glucosamine hydrochloride
Purity
≥99%, BioReagent, suitable for cell culture
Packaging
100g
Price
$79.3
Updated
2025/07/31
Sigma-Aldrich
Product number
1294207
Product name
Glucosamine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$422
Updated
2025/07/31
TCI Chemical
Product number
G0044
Product name
D-(+)-Glucosamine Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$28
Updated
2025/07/31
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D-Glucosamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

glucosamine hydrochloride (glucosamine HCl) is used to adjust the pH of a formulation. It also has anti-static and hair-conditioning properties.

Uses

Novel application of glucosamine is to prepare medical agent for treating vertigo. It is used as food ingredients and additives, raw material for anti cancer and antibiotic drugs.

Uses

Novel application of D-Glucosamine hydrochloride to prepare medical agent for treating vertigo. Found in chitin, in mucoproteins, and in mucopolysaccharides. Antiarthritic. Recent studies show that its chondroprotective activity is related to its antiapoptic properties.

General Description

D-Glucosamine hydrochloride is frequently employed as a dietary supplement to support joint health and alleviate inflammation. It is recognized for its role in the biosynthesis of glycosaminoglycans and subsequently in the formation of cartilage and joint tissues.

Biochem/physiol Actions

Glucosamine is preferred as a nutritional supplement?for individuals with osteoarthritis. It is used as a building block for the production of proteoglycans?and?glycosaminoglycans.

Purification Methods

Crystallise the hydrochloride from 3M HCl, water, and finally water/EtOH/acetone as for galactosamine hydrochloride. [Purchase & Braun Org Synth 26 36 1946, Stacey & Webber Methods in Carbohydrate Chemistry I 228 1962, Academic Press.] The salt has also been purified by dissolving in the minimum volume of boiling H2O (charcoal), filtering and adding a large excess of 95% EtOH (~4 volumes) and stirring vigorously for several hours. Collect the crystals after 4-6hours to give  anomer which mutarotates ] D +100o to +72o (equilibrium, c 1, H2O). A large amount of the -anomer stays in solution. This can be precipitated from the filtrate by adding excess Et2O. The mixture of -plus -anomers has [] D +68.8o (c 4.75, H2O, mutarotating to +70.1o)[Leaback Biochemical Preparations 10 118 1963]. Note that if Et2NH is used instead of Et3N, conversion to the -anomer can be complete (see above). [Stacey et al. Methods in Carbohydrate Chemistry I 3061962, Academic Press; Beilstein 4 IV 2018.]

D-Glucosamine hydrochloride Preparation Products And Raw materials

Raw materials

Potassium hydroxide Citric acid

Preparation Products

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D-Glucosamine hydrochloride Suppliers

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View Lastest Price from D-Glucosamine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
D-Glucosamine hydrochloride 66-84-2
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-02
Wuhan JiyunZen Tech Co., Ltd.
Product
D-Glucosamine hydrochloride 66-84-2
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-07
Wuhan JiyunZen Tech Co., Ltd.
Product
Riboflavin-5-phosphate sodium 66-84-2
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-07

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