ChemicalBook > CAS DataBase List > 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester

3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Product Name
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
CAS No.
639068-43-2
Chemical Name
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
Synonyms
Methisosildenafil-002;Methisosildenafil impure4;Methisosildenafil Impurity;Methisosildenafil Impurity 29;tert-Butyl 3,5-diMethylpiperazine-1-carboxylate;tert-Butyl 3,5-dimethyl-1-piperazinecarboxylate;1,1-Dimethylethyl 3,5-dimethyl-1-piperazinecarboxylate;2-Methyl-2-propanyl 3,5-dimethyl-1-piperazinecarboxylate;3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 3,5-diMethyl-, 1,1-diMethylethyl ester
CBNumber
CB21874141
Molecular Formula
C11H22N2O2
Formula Weight
214.3
MOL File
639068-43-2.mol
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3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:
279.7±15.0 °C(Predicted)
Density 
0.970±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
8.58±0.60(Predicted)
Appearance
Off-white to light yellow Solid
CAS DataBase Reference
639068-43-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D6456
Product name
tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture)
Purity
min. 98.0 %
Packaging
200MG
Price
$60
Updated
2025/07/31
TCI Chemical
Product number
D6456
Product name
tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture)
Purity
min. 98.0 %
Packaging
1G
Price
$150
Updated
2025/07/31
TRC
Product number
B201880
Product name
1-Boc-3,5-dimethylpiperazine
Packaging
500mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
Z4986
Product name
1-Boc-3,5-Dimethylpiperazine
Packaging
1g
Price
$144
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB143070
Product name
tert-Butyl 3,5-dimethylpiperazine-1-carboxylate
Packaging
1g
Price
$101
Updated
2021/12/16
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3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

24424-99-5

108-49-6

639068-43-2

General procedure for the synthesis of 1-Boc-3,5-dimethylpiperazine from di-tert-butyl dicarbonate and 2,6-dimethylpiperazine: 2,6-dimethylpiperazine (200.0 mg, 1.75 mmol) and triethylamine (TEA, 0.6 mL, 4.37 mmol) were dissolved in dichloromethane (DCM, 6.0 mL), and di-tert-butyl dicarbonate (DTBD, 1.5 mmol, 2.6 mL) was added slowly at 0 °C. butyl dicarbonate ((Boc)2O, 458.7 mg, 2.10 mmol) was added slowly at 0 °C. The reaction mixture was stirred at room temperature for 12 hours and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio: DCM:MeOH = 95:5). The fraction containing the target product was collected and evaporated to give tert-butyl 3,5-dimethylpiperazine-1-carboxylate (210.0 mg, 56% yield) as a yellow liquid.1H-NMR (300 MHz, CDCl3) δ: 3.95 (m, 2H), 2.79 (m, 2H), 2.33 (m, 2H), 1.46 (s, 9H), 1.07 (d. 6H, J = 6.3 Hz).

References

[1] Patent: US2005/54850, 2005, A1
[2] Patent: US2014/315888, 2014, A1. Location in patent: Paragraph 0558-0559
[3] Patent: US6235731, 2001, B1
[4] Patent: EP2154135, 2010, A1. Location in patent: Page/Page column 16
[5] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 27-28

3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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639068-43-2, 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl esterRelated Search:

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  • 639068-43-2