3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
- Product Name
- 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
- CAS No.
- 639068-43-2
- Chemical Name
- 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
- Synonyms
- Methisosildenafil-002;Methisosildenafil impure4;Methisosildenafil Impurity;Methisosildenafil Impurity 29;tert-Butyl 3,5-diMethylpiperazine-1-carboxylate;tert-Butyl 3,5-dimethyl-1-piperazinecarboxylate;1,1-Dimethylethyl 3,5-dimethyl-1-piperazinecarboxylate;2-Methyl-2-propanyl 3,5-dimethyl-1-piperazinecarboxylate;3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 3,5-diMethyl-, 1,1-diMethylethyl ester
- CBNumber
- CB21874141
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 639068-43-2.mol
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Property
- Boiling point:
- 279.7±15.0 °C(Predicted)
- Density
- 0.970±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.58±0.60(Predicted)
- Appearance
- Off-white to light yellow Solid
- CAS DataBase Reference
- 639068-43-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D6456
- Product name
- tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture)
- Purity
- min. 98.0 %
- Packaging
- 200MG
- Price
- $60
- Updated
- 2025/07/31
- Product number
- D6456
- Product name
- tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture)
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $150
- Updated
- 2025/07/31
- Product number
- B201880
- Product name
- 1-Boc-3,5-dimethylpiperazine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 19768
- Product name
- 1-Boc-3,5-dimethyl-piperazine,≥95%
- Purity
- ≥95%
- Packaging
- 1G
- Price
- $46.59
- Updated
- 2021/12/16
- Product number
- FB143070
- Product name
- tert-Butyl 3,5-dimethylpiperazine-1-carboxylate
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
24424-99-5
108-49-6
639068-43-2
General procedure for the synthesis of 1-Boc-3,5-dimethylpiperazine from di-tert-butyl dicarbonate and 2,6-dimethylpiperazine: 2,6-dimethylpiperazine (200.0 mg, 1.75 mmol) and triethylamine (TEA, 0.6 mL, 4.37 mmol) were dissolved in dichloromethane (DCM, 6.0 mL), and di-tert-butyl dicarbonate (DTBD, 1.5 mmol, 2.6 mL) was added slowly at 0 °C. butyl dicarbonate ((Boc)2O, 458.7 mg, 2.10 mmol) was added slowly at 0 °C. The reaction mixture was stirred at room temperature for 12 hours and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio: DCM:MeOH = 95:5). The fraction containing the target product was collected and evaporated to give tert-butyl 3,5-dimethylpiperazine-1-carboxylate (210.0 mg, 56% yield) as a yellow liquid.1H-NMR (300 MHz, CDCl3) δ: 3.95 (m, 2H), 2.79 (m, 2H), 2.33 (m, 2H), 1.46 (s, 9H), 1.07 (d. 6H, J = 6.3 Hz).
References
[1] Patent: US2005/54850, 2005, A1
[2] Patent: US2014/315888, 2014, A1. Location in patent: Paragraph 0558-0559
[3] Patent: US6235731, 2001, B1
[4] Patent: EP2154135, 2010, A1. Location in patent: Page/Page column 16
[5] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 27-28
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Suppliers
- Tel
- --
- Fax
- --
- ruf.szilvi@infarmatik.hu
- Country
- Hungary
- ProdList
- 1391
- Advantage
- 69