ChemicalBook > CAS DataBase List > 1,2-Phenylenediacetic acid
1,2-Phenylenediacetic acid
- Product Name
- 1,2-Phenylenediacetic acid
- CAS No.
- 7500-53-0
- Chemical Name
- 1,2-Phenylenediacetic acid
- Synonyms
- RARECHEM AL BO 0119;O-BENZENEDIACETIC ACID;2-Phenylenediacetic acid;O-PHENYLENEDIACETIC ACID;1,2-Benzenediacetic acid;BENZENE-1,2-DIACETIC ACID;1,2-PHENYLENEDIACETIC ACID;o-Phenylenebis(acetic acid);1,2-PhenylenediaceticAcid>o-Phenylenediacetic acid, 98+%
- CBNumber
- CB2204020
- Molecular Formula
- C10H10O4
- Formula Weight
- 194.18
- MOL File
- 7500-53-0.mol
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1,2-Phenylenediacetic acid Property
- Melting point:
- 150-152 °C (lit.)
- Boiling point:
- 290.62°C (rough estimate)
- Density
- 1.2534 (rough estimate)
- refractive index
- 1.5430 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Needle-Like Crystalline Powder
- pka
- 3.90±0.10(Predicted)
- color
- Beige to beige-brown
- BRN
- 2616747
- InChI
- InChI=1S/C10H10O4/c11-9(12)5-7-3-1-2-4-8(7)6-10(13)14/h1-4H,5-6H2,(H,11,12)(H,13,14)
- InChIKey
- MMEDJBFVJUFIDD-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=CC=C1CC(O)=O
- CAS DataBase Reference
- 7500-53-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 131407
- Product name
- 1,2-Phenylenediacetic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $61.4
- Updated
- 2023/06/20
TCI Chemical
- Product number
- P1052
- Product name
- 1,2-Phenylenediacetic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $28
- Updated
- 2025/07/31
TRC
- Product number
- P319930
- Product name
- 1,2-Phenylenediacetic acid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
AK Scientific
- Product number
- J56497
- Product name
- o-Phenylenediaceticacid
- Packaging
- 5g
- Price
- $27
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- JK133996
- Product name
- 1,2-Phenylenediacetic acid
- Packaging
- 5g
- Price
- $32
- Updated
- 2021/12/16
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1,2-Phenylenediacetic acid Chemical Properties,Usage,Production
Chemical Properties
beige to beige-brown needle-like crystalline
Uses
1,2-Phenylenediacetic Acid has been used in the preparation of nanomolar inhibitors of cancer-relevant transcription factor STAT5b.
General Description
A coordination polymer with 1,2-Phenylenediacetic acid was synthesized and characterized by single crystal X-ray diffraction.
Synthesis
613-73-0
7500-53-0
The general procedure for the synthesis of 2,2'-(1,2-phenylene)diacetic acid from 1,2-phenylenediacetonitrile was as follows: 1,2-phenylenediacetonitrile (5.0 g) was dissolved in 50 mL of concentrated hydrochloric acid and heated and refluxed for 3 hours. After the reaction was completed, 30 mL of water was added and heating was continued overnight. The reaction mixture was cooled to room temperature and washed with ether. Subsequently, the organic layer was extracted twice with aqueous sodium carbonate. The aqueous layers were combined, acidified to pH 2-3 with hydrochloric acid and extracted with ether. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated to give 2,2'-(1,2-phenylene)diacetic acid as a light yellow solid in 56% yield with a melting point of 123-125 °C. The product was confirmed by 1H NMR (250 MHz, DMSO-d6): δ 3.58 (s, 4H), 7.20 (s, 4H), 12.34 (br s, 2H); 13C NMR (63 MHz, DMSO-d6): δ 37.1 (2C), 126.8 (2C), 130.6 (2C), 134.1 (2C), 172.4 (2C).
References
[1] Patent: WO2011/41349, 2011, A1. Location in patent: Page/Page column 19-20
[2] Chemische Berichte, 1884, vol. 17, p. 447
[3] Journal of the Chemical Society, 1907, vol. 91, p. 176
[4] Journal of the Chemical Society, 1923, vol. 123, p. 2075
[5] Recueil des Travaux Chimiques des Pays-Bas, 1923, vol. 42, p. 412
1,2-Phenylenediacetic acid Preparation Products And Raw materials
Raw materials
Ethanol
Hexanoic acid
DL-Mandelic acid
Ethyl acetate
Hydrochloric acid
Triethyl orthoacetate
Sodium hydroxide
PETROLEUM ETHER
Sulfuric acid
Preparation Products
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View Lastest Price from 1,2-Phenylenediacetic acid manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 1,2-Phenylenediacetic acid 7500-53-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
Henan Aochuang Chemical Co.,Ltd.
- Product
- 1,2-Phenylenediacetic acid 7500-53-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- 1,2-Phenylenediacetic acid 7500-53-0
- Price
- US $30.00-10.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 100000kg
- Release date
- 2024-08-23
7500-53-0, 1,2-Phenylenediacetic acidRelated Search:
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Allyl phenoxyacetate
2-Hydroxyphenylacetic acid
Methyl phenylacetate
Ethyl phenylacetate
Hyaluronic acid
Phthalic acid
Bis(2-ethylhexyl) phthalate
Methyl 2,2-dimethylphenylacetate
Ethyl 2-(Chlorosulfonyl)acetate
4-Hydroxyphenylacetic acid
Potassium hydrogen phthalate
4-Nitrophenylacetic acid
Phenoxyacetic acid
o-Phenylenediamine
Folic acid
Citric acid
Dimethyl phthalate