synthesis
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Ethyl 2-oxo-4-phenylbutyrate

synthesis
Product Name
Ethyl 2-oxo-4-phenylbutyrate
CAS No.
64920-29-2
Chemical Name
Ethyl 2-oxo-4-phenylbutyrate
Synonyms
KETO ESTER;ETHYL BENZYLPYRUVATE;Ethyl 2-oxy-butyrate;2-oxo-4-phenylhexanoate;2 - oxo -4 - ethyl benzene;ETHYL-2-OXO-4-PHENYLBUTRATE;Ethy 2-oxo-4-phenylbutyrate;Ethyl α-oxobenzenebutanoate;ETHYL 2-OXO-4-PHENYLBUTYRATE;Ethyl 4-phenyl-2-oxobutanoate
CBNumber
CB2207283
Molecular Formula
C12H14O3
Formula Weight
206.24
MOL File
64920-29-2.mol
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Ethyl 2-oxo-4-phenylbutyrate Property

Boiling point:
132 °C/2 mmHg (lit.)
Density 
1.091 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.504(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Oil
color 
Colourless
BRN 
2725083
CAS DataBase Reference
64920-29-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-36/37-26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
B20148
Product name
Ethyl 2-oxo-4-phenylbutyrate, 90+%
Packaging
10g
Price
$42.65
Updated
2024/03/01
Alfa Aesar
Product number
B20148
Product name
Ethyl 2-oxo-4-phenylbutyrate, 90+%
Packaging
50g
Price
$135.65
Updated
2024/03/01
TRC
Product number
E925385
Product name
Ethyl 2-oxo-4-phenylbutyrate, 90+%
Packaging
25g
Price
$105
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0000360
Product name
ETHYL 2-OXO-4-PHENYLBUTYRATE
Purity
95.00%
Packaging
1G
Price
$128.1
Updated
2021/12/16
AK Scientific
Product number
J54157
Product name
Ethyl 2-oxo-4-phenylbutyrate
Packaging
100g
Price
$180
Updated
2021/12/16
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Ethyl 2-oxo-4-phenylbutyrate Chemical Properties,Usage,Production

synthesis

Potassium tert-butoxide (4.3 g, 38.34 mmol) was added in 1 portion to a solution of the diester (8 g, 25.56 mmol) in toluene (80 mL) at 0 °C. After being stirred at the same temperature for 30 min, the reaction mixture was kept at room temperature overnight. Water (100 mL) was added, the phases were separated, and the aqueous phase was extracted with EtOAc (3 × 100 mL). The combined organic extracts  were dried and evaporated. The residue was purifified by flflash chromatography  eluting with EtOAc:light petroleum (1:9) to give 5.6 g (78%) of the keto-ester as an orange oil.

Chemical Properties

light yellow oily liquid

Uses

Ethyl 2-oxo-4-phenylbutyrate may be used in the synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate, an important chiral precursor for angiotensin-converting enzyme (ACE) inhibitor.

General Description

Ethyl 2-oxo-4-phenylbutyrate is an aliphatic α-ketoester. Bioreduction of ethyl 2-oxo-4-phenylbutyrate is reported to yield ethyl (R)-2-hydroxy-4-phenylbutanoate. The effect of ionic liquid on the asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate by Saccharomyces cerevisiae has been reported. Asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate using a bacterial reductase is reported. Enantioselective hydrogenation of ethyl 2-oxo-4-phenylbutyrate using homogeneous Rh-diphosphine and heterogeneous Pt/Al2O3-cinchona catalysts has been reported.

Ethyl 2-oxo-4-phenylbutyrate Preparation Products And Raw materials

Raw materials

Preparation Products

Enalapril Spirapril
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View Lastest Price from Ethyl 2-oxo-4-phenylbutyrate manufacturers

airuikechemical co., ltd.
Product
ethyl 2-oxo-4-phenylbutyrate 64920-29-2
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09
Hebei Yanxi Chemical Co., Ltd.
Product
Ethyl 2-oxo-4-phenylbutyrate 64920-29-2
Price
US $40.00-5.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
15 tons
Release date
2023-09-14
Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl 2-oxo-4-phenylbutyrate 64920-29-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-07

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