synthesis
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Ethyl 2-oxo-4-phenylbutyrate

synthesis
Product Name
Ethyl 2-oxo-4-phenylbutyrate
CAS No.
64920-29-2
Chemical Name
Ethyl 2-oxo-4-phenylbutyrate
Synonyms
KETO ESTER;ETHYL BENZYLPYRUVATE;Ethyl 2-oxy-butyrate;2-oxo-4-phenylhexanoate;2 - oxo -4 - ethyl benzene;ETHYL-2-OXO-4-PHENYLBUTRATE;Ethy 2-oxo-4-phenylbutyrate;Ethyl α-oxobenzenebutanoate;ETHYL 2-OXO-4-PHENYLBUTYRATE;Ethyl-2-oxo-4-pheny1Butyrate
CBNumber
CB2207283
Molecular Formula
C12H14O3
Formula Weight
206.24
MOL File
64920-29-2.mol
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Ethyl 2-oxo-4-phenylbutyrate Property

Boiling point:
132 °C/2 mmHg (lit.)
Density 
1.091 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.504(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Oil
color 
Colourless
BRN 
2725083
CAS DataBase Reference
64920-29-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-36/37-26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
B20148
Product name
Ethyl 2-oxo-4-phenylbutyrate, 90+%
Packaging
10g
Price
$42.65
Updated
2024/03/01
Alfa Aesar
Product number
B20148
Product name
Ethyl 2-oxo-4-phenylbutyrate, 90+%
Packaging
50g
Price
$135.65
Updated
2024/03/01
TRC
Product number
E925385
Product name
Ethyl 2-oxo-4-phenylbutyrate, 90+%
Packaging
25g
Price
$105
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0000360
Product name
ETHYL 2-OXO-4-PHENYLBUTYRATE
Purity
95.00%
Packaging
1G
Price
$128.1
Updated
2021/12/16
AK Scientific
Product number
J54157
Product name
Ethyl 2-oxo-4-phenylbutyrate
Packaging
100g
Price
$180
Updated
2021/12/16
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Ethyl 2-oxo-4-phenylbutyrate Chemical Properties,Usage,Production

synthesis

Potassium tert-butoxide (4.3 g, 38.34 mmol) was added in 1 portion to a solution of the diester (8 g, 25.56 mmol) in toluene (80 mL) at 0 °C. After being stirred at the same temperature for 30 min, the reaction mixture was kept at room temperature overnight. Water (100 mL) was added, the phases were separated, and the aqueous phase was extracted with EtOAc (3 × 100 mL). The combined organic extracts  were dried and evaporated. The residue was purifified by flflash chromatography  eluting with EtOAc:light petroleum (1:9) to give 5.6 g (78%) of the keto-ester as an orange oil.

Chemical Properties

light yellow oily liquid

Uses

Ethyl 2-oxo-4-phenylbutyrate may be used in the synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate, an important chiral precursor for angiotensin-converting enzyme (ACE) inhibitor.

General Description

Ethyl 2-oxo-4-phenylbutyrate is an aliphatic α-ketoester. Bioreduction of ethyl 2-oxo-4-phenylbutyrate is reported to yield ethyl (R)-2-hydroxy-4-phenylbutanoate. The effect of ionic liquid on the asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate by Saccharomyces cerevisiae has been reported. Asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate using a bacterial reductase is reported. Enantioselective hydrogenation of ethyl 2-oxo-4-phenylbutyrate using homogeneous Rh-diphosphine and heterogeneous Pt/Al2O3-cinchona catalysts has been reported.

Ethyl 2-oxo-4-phenylbutyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-oxo-4-phenylbutyrate Suppliers

Henan yingchuang
Tel
16650708709
Fax
qq:778660296
Email
hnyingchuang@163.com
Country
China
ProdList
3924
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
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56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
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61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
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View Lastest Price from Ethyl 2-oxo-4-phenylbutyrate manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Ethyl 2-oxo-4-phenylbutyrate 64920-29-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-12-05
Hebei Weibang Biotechnology Co., Ltd
Product
Ethyl 2-oxo-4-phenylbutyrate 64920-29-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
Ethyl 2-oxo-4-phenylbutyrate 64920-29-2
Price
US $40.00-5.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
15 tons
Release date
2023-09-14

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