1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent

Description Reference

Product Name: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent
CAS No.: 887144-97-0
Chemical Name: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent
Synonyms: Togni Reagent;3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole;1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole;togni's reagent;togni's reagent;3,3-DMethyl-1-(trifluoroMethyl)-1,2-benziodoxole;3,3-Dimethyl-1-(trifluoromethyl)-1,2-benzodioxole;1,3-Dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-b;1,2-Benziodoxole,3,3-dimethyl-1-(trifluoromethyl)-;3,3-dimethyl-1-(trifluoromethyl)-1λ3,2-benziodoxole
CBNumber: CB22101080
Molecular Formula: C10H10F3IO
Formula Weight: 330.09
MOL File: 887144-97-0.mol

More

Less

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Property

Melting point:: 75-79 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder
color: white to off-white
Stability:: Moisture Sensitive
InChI: InChI=1S/C10H10F3IO/c1-9(2)7-5-3-4-6-8(7)14(15-9)10(11,12)13/h3-6H,1-2H3
InChIKey: HVAPLSNCVYXFDQ-UHFFFAOYSA-N
SMILES: I1(C(F)(F)F)C2=CC=CC=C2C(C)(C)O1

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
RIDADR: 1325
WGK Germany: 3
TSCA: No
HazardClass: 4.1
PackingGroup: Ⅲ
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696641
Product name: 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Purity: 95%
Packaging: 1g
Price: $456
Updated: 2025/07/31

Sigma-Aldrich

Product number: 696641
Product name: 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Purity: 95%
Packaging: 5g
Price: $881
Updated: 2025/07/31

TCI Chemical

Product number: T2624
Product name: 1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $210
Updated: 2025/07/31

TCI Chemical

Product number: T2624
Product name: 1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole
Purity: >97.0%(HPLC)
Packaging: 5g
Price: $729
Updated: 2025/07/31

Sigma-Aldrich

Product number: 696641
Product name: 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole
Purity: 95%
Packaging: 250mg
Price: $123
Updated: 2025/07/31

More

Less

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Chemical Properties,Usage,Production

Description

1,3-dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is in the form of colorless, white solid. It is soluble in all common organic solvents. It is used as effective and very versatile reagent for trifluoromethylation reactions of a variety of compounds including secondary and primary aryland alkylphospines, phenols, peptides containing cysteine residues by SPPS and electrophilic S-trifluoromethylation, arenes and N-heterocycles, and electrophilic N-trifluoromethylation of arozoles.

Reference

J. Charpentier, N. Früh, A. Togni, Electrophilic Trifluoromethylation by use of hypervalent iodine reagents, Chemical Reviews, 2015, vol. 115, pp. 650-682

Chemical Properties

White to light yellow solid

Uses

Mild, electrophilic, hypervalent iodine CF3 reagent effective for the trifluoromethylation of a wide range of substrates.

Uses

Togni’s Reagent is used in trifluoromethylation reactions.

reaction suitability

reaction type: C-C Bond Formation

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent Suppliers

China 153 India 4 Japan 1 Switzerland 1 United Kingdom 2 United States 12 Global 173

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

More

Less

View Lastest Price from 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Togni's Reagent 887144-97-0
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Henan Aochuang Chemical Co.,Ltd.

Product: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent 887144-97-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Shaanxi Dideu New Materials Co. Ltd

Product: 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent 887144-97-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-28

887144-97-0, 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis ReagentRelated Search:

(Difluoromethyl)bis(2,5-dimethylphenyl)sulfonium Tetrafluoroborate 1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one (PERFLUORO-N-HEXYL)PHENYLIODONIUM TRIFLUOROMETHANESULFONATE Pyrazine Lactic acid N,N-Dimethylacetamide N,N-Dimethylaniline Diphenyl(trifluoromethyl)sulfonium trifluoromethanesulfonate 2,2,2-trifluoroethyl(phenyl)iodonium trifluoromethanesulfonate diphenyl(2,2,2-trifluoroethyl)sulfanium trifluoromethanesulfonate (perfluoroethyl)diphenylsulfonium trifluoromethanesulfonate Mesityl(2,2,2-trifluoroethyl)iodonium trifluoromethanesulfonate (difluoromethyl)(2,4-dimethylphenyl)(phenyl)sulfonium tetrafluoroborate Iodonium, (1,1,2,2,3,3,4,4,4-nonafluorobutyl)phenyl-,1,1,1-trifluoromethanesulfonate (2,2-difluoroethyl)diphenylsulfonium trifluoromethanesulfonate 2-IODOISOPROPYLBENZENE Trifluoromethyl iodide 1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent

1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, Tognis Reagent

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole

1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole

1,3-dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole

1,3-Dhydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-benziodoxole

3,3-DMethyl-1-(trifluoroMethyl)-1,2-benziodoxole

1,3-Dihydro-3,3-diMethyl-1-(trifluoroMethyl)-1,2-b

3,3-DiMethyl-1-(trifluoroMethyl)-1,2-benziodoxole 95%

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole / TOGNI A

1,2-Benziodoxole,3,3-dimethyl-1-(trifluoromethyl)-

Togni Reagent

3,3-DiMethyl-1-(trifluoroMethyl)-1,2-benziodoxole (Togni‘s reagent)

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, >=98%

3,3-Dimethyl-1-(trifluoromethyl)-1,2- benziodoxole (Togni's reagent I)

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benzodioxole

1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole, 97%, for synthesis

3,3-dimethyl-1-(trifluoromethyl)-1$l^{3},2-benziodoxole

3,3-dimethyl-1-(trifluoromethyl)-1λ3,2-benziodoxole

Togni`s Reagent (3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole) extrapure, 97%

togni's reagent

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole (ACI)

togni's reagent

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole - [D52498]

887144-97-0

C10H10F3IO