ChemicalBook > CAS DataBase List > 2-[(Diphenylmethyl)thio]acetic acid

2-[(Diphenylmethyl)thio]acetic acid

Product Name
2-[(Diphenylmethyl)thio]acetic acid
CAS No.
63547-22-8
Chemical Name
2-[(Diphenylmethyl)thio]acetic acid
Synonyms
AKOS BC-179;AKOS BC-1797;ArModafinil IMpurity B;(BENZHYDRYLTHIO)ACETIC ACID;2-(benzhydrylthio)acetic acid;(Benzhydrylthio)aceticAcid>BENZHYDRYLSULFANYL ACETIC ACID;2-PHENYL METHYLTHIO ACETIC ACID;2-[(diphenylmethyl)thio]acetate;2-[(DIPHENYLMETHYL)THIO]ACETIC ACID
CBNumber
CB2211062
Molecular Formula
C15H14O2S
Formula Weight
258.34
MOL File
63547-22-8.mol
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2-[(Diphenylmethyl)thio]acetic acid Property

Melting point:
127-1290C
Boiling point:
408.6±33.0 °C(Predicted)
Density 
1.223±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
3.68±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C15H14O2S/c16-14(17)11-18-15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H,16,17)
InChIKey
HTHFEDOFDBZPRX-UHFFFAOYSA-N
SMILES
C(O)(=O)CSC(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference
63547-22-8(CAS DataBase Reference)
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Safety

HS Code 
2930.90.2900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4175
Product name
(Benzhydrylthio)acetic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$111
Updated
2025/07/31
TCI Chemical
Product number
B4175
Product name
(Benzhydrylthio)acetic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$335
Updated
2025/07/31
TRC
Product number
D491830
Product name
2-[(Diphenylmethyl)thio]aceticAcid
Packaging
5g
Price
$580
Updated
2021/12/16
AK Scientific
Product number
O876
Product name
2-[(Diphenylmethyl)thio]aceticacid
Packaging
25g
Price
$41
Updated
2021/12/16
AK Scientific
Product number
J51031
Product name
2-[(Diphenylmethyl)thio]aceticacid
Packaging
100g
Price
$75
Updated
2021/12/16
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2-[(Diphenylmethyl)thio]acetic acid Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Powder

Uses

Intermediate in the preparation of Modafinil

Synthesis

91-01-0

68-11-1

63547-22-8

General procedure for the synthesis of 2-[(diphenylmethyl)mercapto]acetic acid from diphenylmethanol and mercaptoacetic acid: mercaptoacetic acid (10.5 g, 7.92 mL, density = 1.325 g/mL, 0.114 mol) was added slowly and dropwise to a solution of trifluoroacetic acid (100 mL) in diphenylmethanol. During the dropwise addition, precipitate formation was observed within 30 minutes. The reaction mixture was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the precipitate was collected by filtration and washed sequentially with water (3 x 50 mL) and hexane. The crude product was purified by recrystallization from EtOAc/hexane mixed solvent to give colorless crystals of 2-[(diphenylmethyl)thio]acetic acid. Yield: 17.93 g (64% yield). Melting point: 121°C.

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 20, p. 2984 - 2997
[2] Tetrahedron Asymmetry, 2004, vol. 15, # 6, p. 1053 - 1058
[3] Tetrahedron Asymmetry, 2005, vol. 16, # 21, p. 3507 - 3511
[4] Patent: US7553646, 2009, B2
[5] Molecules, 2012, vol. 17, # 9, p. 10446 - 10458

2-[(Diphenylmethyl)thio]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(Diphenylmethyl)thio]acetic acid Suppliers

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View Lastest Price from 2-[(Diphenylmethyl)thio]acetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-[(Diphenylmethyl)thio]acetic acid 63547-22-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-06
Career Henan Chemical Co
Product
2-[(Diphenylmethyl)thio]acetic acid 63547-22-8
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08

63547-22-8, 2-[(Diphenylmethyl)thio]acetic acidRelated Search:

Mercaptoacetic acid Calcium thioglycolate POTASSIUM THIOGLYCOLATE Ammonium thioglycolate Sodium thioglycolate Methyl thioglycolate Thiosalicylic acid Ethyl 2-(Chlorosulfonyl)acetate 2-Ethylhexyl mercaptoacetate Phenylacetic acid Acetic anhydride (METHYLTHIO)ACETIC ACID Modafinil Carboxylate-d5 Methyl Ester 2-Benzhydrylsulphinylacetic acid ACETIC ACID, [(DIPHENYLMETHYL)SULFINYL]-, ETHYL ESTER Modafinil Carboxylate-d5 Modafinil Carboxylate Methyl Ester (Diphenylmethyl)Thio Acetic Acid Ethyl Ester

  • 2-PHENYL METHYLTHIO ACETIC ACID
  • 2-[(DIPHENYLMETHYL)THIO]ACETIC ACID
  • AKOS BC-1797
  • 2-(Diphenylmethyl)sulfide acetic acid
  • BENZHYDRYLSULFANYL ACETIC ACID
  • (BENZHYDRYLTHIO)ACETIC ACID
  • AKOS BC-179
  • Acetic acid, [(diphenylmethyl)thio]-
  • 2-(benzhydrylthio)acetic acid
  • Acetic acid, [(diphenylMethyl)thio]- (9CI)
  • ArModafinil IMpurity B
  • 2-[(diphenylmethyl)thio]acetate
  • 2-[(diphenylmethyl)sulfanyl]acetic acid
  • (Benzhydrylthio)aceticAcid&gt
  • Acetic acid, 2-[(diphenylmethyl)thio]-
  • Armodafinil Impurity 3/(2-benzhydryl thio)acetic acid
  • 2-[(DiphenyI Methyl) Thio] Acetic Acid
  • 63547-22-8
  • 62547-22-8
  • C15H14O2S
  • Aromatics Compounds
  • Benzene series
  • Aromatics
  • Sulfur & Selenium Compounds