Gonadorelin acetate
- Product Name
- Gonadorelin acetate
- CAS No.
- 34973-08-5
- Chemical Name
- Gonadorelin acetate
- Synonyms
- Gonaderelin acetate;Gonadorelin Acetate 2mg;GONADORELIN(2MG);Gonadelin Acetate;GONADORELIN ACETATE;Gonadorelin Acetate/GnRH;Gonadorelin Acetate(acetate);(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methy
- CBNumber
- CB22130587
- Molecular Formula
- C57H79N17O15
- Formula Weight
- 1242.36
- MOL File
- 34973-08-5.mol
Gonadorelin acetate Property
- Melting point:
- >155oC (dec.)
- storage temp.
- Hygroscopic, Refrigerator, Under inert atmosphere
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- NGCGMRBZPXEPOZ-NWVXUHCVNA-N
- CAS DataBase Reference
- 34973-08-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 24240
- Product name
- Gonadorelin (acetate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24240
- Product name
- Gonadorelin (acetate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 24240
- Product name
- Gonadorelin (acetate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- G766713
- Product name
- GonadorelinAcetate
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 5021AF
- Product name
- GonadorelinAcetate
- Packaging
- 5mg
- Price
- $133
- Updated
- 2021/12/16
Gonadorelin acetate Chemical Properties,Usage,Production
Description
Gonadorelin Acetate is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.
Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Description
Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.
Uses
Gonadorelin Acetate is used in various agricultural and biological studies. It was used in the study of ovulation synchronization in dairy cows.
Uses
Gonad-stimulating principle.
Application
Ovarian follicular cysts (veterinary medicine)
Use in reproduction medicine
Diagnosis of the hypothalamic-pituitary-gonadal axis function
Cryptorchism
Synchronization of ovulation (veterinary medicine)
Indications
Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species.
Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.
brand name
Lutrepulse (Ferring Pharmaceuticals).
Biological Activity
Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle- stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (Item No. 23555; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.
Pharmacology
Gonadorelin is an agonist of the GnRH receptor and is used to induce the secretion of the gonadotropins follicle-stimulating hormone and luteinizing hormone from the pituitary gland and to increase sex hormone production by the gonads.
Gonadorelin has a distribution half-life of 2 to 10 minutes and a very short terminal half-life of 10 to 40 minutes. It is metabolized by hydrolysis into smaller peptide components.
Side effects
Gonadorelin side effects: headache; flushing; nausea or abdominal discomfort; dizziness or lightheadedness; pain, swelling, or itching at the injection site; or. skin rash.
Safety Profile
A poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Preparation and handling
Gonadorelin (acetate) is supplied as a crystalline solid. A stock solution may be made by dissolving the gonadorelin (acetate) in the solvent of choice. Gonadorelin (acetate) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of gonadorelin (acetate) in ethanol is approximately 0.25 mg/ml and approximately 30 mg/ml in DMSO and DMF.
Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of gonadorelin (acetate) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of gonadorelin (acetate) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.
Gonadorelin acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Gonadorelin acetate manufacturers
- Product
- Gonadorelin Acetate 34973-08-5
- Price
- US $50.00-30.00/box
- Min. Order
- 1box
- Purity
- 99.99%
- Supply Ability
- 1000
- Release date
- 2024-03-14
- Product
- Gonadorelin Acetate 34973-08-5
- Price
- US $40.00-20.00/box
- Min. Order
- 1box
- Purity
- 99.9%
- Supply Ability
- 1000 box
- Release date
- 2024-03-14
- Product
- Gonadorelin 34973-08-5
- Price
- US $30.00/box
- Min. Order
- 1box
- Purity
- 98%
- Supply Ability
- 2000box
- Release date
- 2024-03-20