2-Chloro-4-iodopyridine-3-carboxaldehyde

Uses

Product Name: 2-Chloro-4-iodopyridine-3-carboxaldehyde
CAS No.: 153034-90-3
Chemical Name: 2-Chloro-4-iodopyridine-3-carboxaldehyde
Synonyms: 2-Chloro-4-iodonicotinaldehyde;CAS:153034-90-3;oro-4-iodo-pyridine-3-carbaL;2-CHLORO-3-FORMYL-4-IODOPYRIDINE;2-Chloro-4-Iodopyridine-3-Formaldehyde;2-CHLORO-4-IODO-PYRIDINE-3-CARBALDEHYDE;2-CHLORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;2-Chloro-4-iodo-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 2-chloro-4-iodo-;2-Chloro-4-iodo-pyridine-3-carbaldehyde ,97%
CBNumber: CB2213208
Molecular Formula: C6H3ClINO
Formula Weight: 267.45
MOL File: 153034-90-3.mol

More

Less

2-Chloro-4-iodopyridine-3-carboxaldehyde Property

Melting point:: 87-92 °C
Boiling point:: 326.6±42.0 °C(Predicted)
Density: 2.083±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: -1.53±0.10(Predicted)
Appearance: Light yellow to yellow Solid
Sensitive: Air & Light Sensitive
InChI: InChI=1S/C6H3ClINO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H
InChIKey: OPZCXONVRBYGHX-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(I)=C1C=O
CAS DataBase Reference: 153034-90-3(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 722596
Product name: 2-Chloro-4-iodopyridine-3-carboxaldehyde
Purity: 97%
Packaging: 1g
Price: $195
Updated: 2025/07/31

TRC

Product number: C360260
Product name: 2-Chloro-3-formyl-4-iodopyridine
Packaging: 250mg
Price: $110
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK241405
Product name: 2-Chloro-4-iodo-pyridine-3-carbaldehyde
Purity: 97%
Packaging: 1g
Price: $114
Updated: 2021/12/16

AK Scientific

Product number: N414
Product name: 2-Chloro-4-iodopyridine-3-carboxaldehyde
Packaging: 5g
Price: $114
Updated: 2021/12/16

ChemScene

Product number: CS-D0962
Product name: 2-Chloro-4-iodopyridine-3-carbaldehyde
Purity: 98.72%
Packaging: 10g
Price: $109
Updated: 2021/12/16

More

Less

2-Chloro-4-iodopyridine-3-carboxaldehyde Chemical Properties,Usage,Production

Uses

2-Chloro-4-iodopyridine-3-carboxaldehyde is an organic heterocyclic compound that can be used as a pharmaceutical intermediate.

Chemical Properties

Yellow-green solid

Synthesis

78607-36-0

109-94-4

153034-90-3

Example 1: Synthesis of N-(2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl)cyclopropanecarboxamide Step 1: Preparation of 2-chloro-4-iodonicotinaldehyde A solution of 2-chloro-3-iodopyridine (5.0 g, 21 mmol) in anhydrous THF (30 mL) was slowly added dropwise to a solution of lithium diisopropylammonium (15 mL, 30 mmol) in anhydrous THF (50 mL) that was pre-cooled to -78 °C. The reaction mixture was stirred continuously at -78 °C for 3 hours. Subsequently, ethyl formate (4.0 g, 54 mmol) was added to the reaction system and stirring was continued at the same temperature for 1.5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (10 mL), after which the mixture was slowly warmed to room temperature. THF was removed by distillation under reduced pressure after addition of 2 M HCl (50 mL).The aqueous phase was extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: ether/petroleum ether=1:4) to afford the target compound 2-chloro-4-iodonicotinaldehyde as a yellow solid (3.0 g, 54% yield). NMR (500MHz, CDCl3): δ10.22 (s, 1H), 8.09 (d, J=5.0Hz, 1H), 7.95 (d, J=5.0Hz, 1H).

References

[1] Synthetic Communications, 1996, vol. 26, # 23, p. 4421 - 4436
[2] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[3] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 5, p. 1039 - 1044
[4] Patent: WO2012/66061, 2012, A1. Location in patent: Page/Page column 76-77

2-Chloro-4-iodopyridine-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

Hexane Nitrogen Ethyl formate Potassium carbonate Sodium Diisopropylamine Lithium diisopropylamide Tetrahydrofuran Diethyl ether Magnesium sulfate 2-Chloro-3-iodopyridine n-Butyllithium

Preparation Products

More

Less

2-Chloro-4-iodopyridine-3-carboxaldehyde Suppliers

China 158 Germany 4 India 2 United Kingdom 7 United States 20 Global 191

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

ETA SCIENTIFIC Co.,Ltd

Tel: --
Fax: --
Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

Eurolabs Limited

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6309
Advantage: 46

Fulcrum Scientific Ltd.

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6565
Advantage: 38

More

Less

View Lastest Price from 2-Chloro-4-iodopyridine-3-carboxaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-4-iodopyridine-3-carboxaldehyde 153034-90-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Honest Joy Holdings Limited

Product: 2-Chloro-4-iodopyridine-3-carboxaldehyde 153034-90-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.1%
Supply Ability: 100 tons
Release date: 2022-02-08

Dideu Industries Group Limited

Product: 2-Chloro-4-iodopyridine-3-carboxaldehyde 153034-90-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-01

153034-90-3, 2-Chloro-4-iodopyridine-3-carboxaldehydeRelated Search:

Clopidol 2-Bromopyridine-5-carbaldehyde 2-Bromo-3-iodopyridine 2-Bromo-4-iodopyridine 2-BROMO-3-FORMYLPYRIDINE 2-Chloro-4-iodopyridine 2-Chloro-5-chloromethylpyridine Difluorochloromethane 2-CHLORO-4-IODO-3-METHYLPYRIDINE 2-CHLORO-4-IODO-NICOTINIC ACID METHYL ESTER 2-CHLORO-4-IODO-NICOTINIC ACID 4-Iodopyridine 2-CHLORO-4-IODO-NICOTINIC ACID ETHYL ESTER 4-Iodo-3-methylpyridine 2-Chloro-4-iodopyridine-3-carboxaldehyde pyridylaldehyde

2-CHLORO-4-IODO-PYRIDINE-3-CARBALDEHYDE

2-CHLORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE

2-CHLORO-3-FORMYL-4-IODOPYRIDINE

2-Chloro-3-formyl-4-iodopyridine, 2-Chloro-4-iodopyridine-3-carboxaldehyde

2-Chloro-4-iodonicotinaldehyde

2-Chloro-4-iodo-pyridine-3-carbaldehyde ,97%

2-Chloro-4-iodo-3-pyridinecarboxaldehyde

2-Chloro-4-Iodopyridine-3-Formaldehyde

oro-4-iodo-pyridine-3-carbaL

3-Pyridinecarboxaldehyde, 2-chloro-4-iodo-

2-Chloro-4-iodopyridine-3-carboxaldehyde ISO 9001：2015 REACH

CAS:153034-90-3

153034-90-3

153034-90-4

C6H3CllNO

C6H3ClINO

Heterocycle-Pyridine series

Boronic Acid

Aldehydes

Building Blocks

C1 to C6

C5 to C6

C6 to C7

Carbonyl Compounds

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Organic Building Blocks

Pyridine

Pyridines