ChemicalBook > CAS DataBase List > 4'-Methoxyacetoacetanilide

4'-Methoxyacetoacetanilide

Product Name: 4'-Methoxyacetoacetanilide
CAS No.: 5437-98-9
Chemical Name: 4'-Methoxyacetoacetanilide
Synonyms: AAPA;R89439;alpha-APA;AKOS B029142;P-ACETOACETANISIDE;p-Acetoacetanisidine;P-ACETOACETANISIDIDE;4'-Methoxyacetoaceta;ACETOACET-P-ANISIDIDE;AcetoAcet-P-Anisilide
CBNumber: CB2224824
Molecular Formula: C11H13NO3
Formula Weight: 207.23
MOL File: 5437-98-9.mol

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4'-Methoxyacetoacetanilide Property

Melting point:: 115-118 °C
Boiling point:: 346.25°C (rough estimate)
Density: 1.1878 (rough estimate)
vapor pressure: 0.001Pa at 20℃
refractive index: 1.5100 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 11.35±0.46(Predicted)
form: Powder
color: White to Blue
Water Solubility: soluble
LogP: 0.85 at 23℃ and pH8.3-8.6
CAS DataBase Reference: 5437-98-9(CAS DataBase Reference)
NIST Chemistry Reference: Butanamide, 3-oxo-n-(4-methoxyphenyl)-(5437-98-9)
EPA Substance Registry System: Butanamide, N-(4-methoxyphenyl)-3-oxo- (5437-98-9)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 26-36/37/39
RTECS: AK4598010
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1307
Product name: p-Acetoacetanisidide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: A1307
Product name: p-Acetoacetanisidide
Purity: >98.0%(HPLC)(N)
Packaging: 500g
Price: $143
Updated: 2025/07/31

TRC

Product number: M266430
Product name: N-(4-Methoxyphenyl)-3-oxobutanamide
Packaging: 50g
Price: $800
Updated: 2021/12/16

AK Scientific

Product number: J54679
Product name: p-Acetoacetaniside
Packaging: 5g
Price: $20
Updated: 2021/12/16

Matrix Scientific

Product number: 075134
Product name: p-Acetoacetanisidide
Purity: 95+%
Packaging: 5g
Price: $70
Updated: 2021/12/16

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4'-Methoxyacetoacetanilide Chemical Properties,Usage,Production

Chemical Properties

WHITE TO VERY SLIGHTLY YELLOW POWDER

Uses

N-(4-Methoxyphenyl)-3-oxobutanamide is an intermediate in the synthesis of Tafenoquine-d3 Succinate is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.

Synthesis Reference(s)

The Journal of Organic Chemistry, 11, p. 803, 1946 DOI: 10.1021/jo01176a024

Synthesis

141-97-9

104-94-9

5437-98-9

GENERAL STEPS: In a 100 mL round-bottomed flask, ethyl acetoacetate (0.03 mol) was added to a stirring solution of p-aminoanisole (0.01 mol) dissolved in 10 mL of PEG-300. The reaction mixture was refluxed at 120 °C for 1.5-2 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted with cold ether (3 x 10 mL). The organic phases were combined and purified by column chromatography (eluent: hexane solution of 10-25% ethyl acetate) to afford the target product N-(4-methoxyphenyl)-3-oxobutylamide (3a-p). The structure of the final product was confirmed by methods reported in the literature.

References

[1] Synthetic Communications, 2000, vol. 30, # 20, p. 3709 - 3718
[2] Heterocycles, 2008, vol. 75, # 11, p. 2681 - 2701
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 14, p. 3171 - 3177
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 13, p. 1639 - 1641
[5] Journal of Chemical Sciences, 2014, vol. 126, # 1, p. 187 - 195

4'-Methoxyacetoacetanilide Preparation Products And Raw materials

Raw materials

Acetyl ketene

Preparation Products

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4'-Methoxyacetoacetanilide Suppliers

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View Lastest Price from 4'-Methoxyacetoacetanilide manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4'-Methoxyacetoacetanilide 5437-98-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-21

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-Methoxyacetoacetanilide 5437-98-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4"-Methoxyacetoacetanilide 5437-98-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

5437-98-9, 4'-MethoxyacetoacetanilideRelated Search:

p-Anisidine 2'-Chloroacetoacetanilide Acetylacetone Acetoacetamide p-Acetotoluidide m-Anisidine Acetanilide 2-BENZOYLACETANILIDE N-ACETYL-L-TYROSINE ETHYL ESTER 4-Aminoveratrole 4'-Aminoacetanilide 4-(Trifluoromethoxy)aniline 4'-Nitroacetanilide Acetazolamide 2,5-Dimethoxyacetoacetanilide N-(4-Methylphenyl)-3-oxobutanamide 4'-Chloroacetoacetanilide N-(Acetoacetyl)anthranilic acid

acetoacetyl-p-acetanisidine

ACETOACET-P-ANISIDIDE

ACETO ACET P-ANISIDINE

AAPA

AKOS B029142

Acetoacetanilide, 4'-methoxy-

alpha-APA

Butanamide, N-(4-methoxyphenyl)-3-oxo-

Butanamide, N-(4-methoxyphenyl)-oxo-

n-(4-methoxyphenyl)-3-oxo-butanamid

N-(4-Methoxyphenyl)acetoacetamide

n-(4-methoxyphenyl)-oxo-butanamid

4'-methoxyacetoacetanilide

4’-methoxy-acetoacetanilid

4-methoxyl-n-acetoacetanilide

p-Acetoacetanisidine

para-Acetoacetanisidide

p-Methoxyacetoacetanilide

-Methoxyacetoacetanilide

R89439

P-ACETOACETANISIDE

P-ACETOACETANISIDIDE

N-(4-METHOXYPHENYL)-3-OXOBUTANAMIDE

N-(4-METHOXYPHENYL)-3-OXO-BUTYRAMIDE

N-ACETOACETYL-P-ANISIDINE

N-ACETOACETYL-4-METHOXYANILINE

Acetoacet-p-anisidide(AAPA)

acetoacetate-p-anisidide

Acetoacetyl-p-methoxyaniline

4-Methoxy-N-Acetoacetanilide

Acetoacetanisidide,98%

ACETOACET-P-ANISIDEIDE

AcetoAcet-P-Anisilide

p-Acetoacetaniside,98%

N-Acetoacetyl-p-anisidine N-Acetoacetyl-4-methoxyaniline

4'-Methoxyacetoaceta

<i>p</i>-Acetoacetanisidide

p-Acetoacetanisidide &gt

4'-Methoxyacetoacetanilide ISO 9001：2015 REACH

p-AnisidineAcylAcyl(AAPA)

5437-98-9

CH3COCH2CONHC6H4OCH3

Aromatic amine products

Intermediates of Dyes and Pigments