1-(Triphenylmethyl)imidazole
- Product Name
- 1-(Triphenylmethyl)imidazole
- CAS No.
- 15469-97-3
- Chemical Name
- 1-(Triphenylmethyl)imidazole
- Synonyms
- CDD 3501;N-TRITYLIMIDAZOLE;1-TRITYLIMIDAZOLE;1-TRITYL-1H-IMIDAZOLE;ClotriMazole IMpurity F;Clotrimazole Impurity 6;Clotrimazole EP Impurity F;(TRIPHENYLMETHYL)IMIDAZOLE;1-(TRIPHENYLMETHYL)IMIDAZOLE;N-(Triphenylmethyl)imidazole
- CBNumber
- CB2228231
- Molecular Formula
- C22H18N2
- Formula Weight
- 310.39
- MOL File
- 15469-97-3.mol
1-(Triphenylmethyl)imidazole Property
- Melting point:
- 220-224 °C(lit.)
- Boiling point:
- 451.3±14.0 °C(Predicted)
- Density
- 1.05±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 6.34±0.30(Predicted)
- color
- White to Off-White
- Water Solubility
- Insoluble in water.
- BRN
- 238171
- InChI
- InChI=1S/C22H18N2/c1-4-10-19(11-5-1)22(24-17-16-23-18-24,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-18H
- InChIKey
- NPZDCTUDQYGYQD-UHFFFAOYSA-N
- SMILES
- C1N(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1
- CAS DataBase Reference
- 15469-97-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR3005
- Product name
- Clotrimazole Impurity F
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $351.5
- Updated
- 2025/07/31
- Product number
- 524891
- Product name
- 1-(Triphenylmethyl)imidazole
- Purity
- 97%
- Packaging
- 25g
- Price
- $699
- Updated
- 2025/07/31
- Product number
- T3316
- Product name
- 1-Tritylimidazole
- Packaging
- 5G
- Price
- $72
- Updated
- 2025/07/31
- Product number
- T3316
- Product name
- 1-Tritylimidazole
- Packaging
- 25G
- Price
- $288
- Updated
- 2025/07/31
- Product number
- T888120
- Product name
- 1-Tritylimidazole
- Packaging
- 25g
- Price
- $400
- Updated
- 2021/12/16
1-(Triphenylmethyl)imidazole Chemical Properties,Usage,Production
Uses
1-(Triphenylmethyl)imidazole may be used in the synthesis of 1,2,5-trisubstituted imidazole derivatives.
Uses
1-Tritylimidazole is a Clotrimazole (C587400) analog as antifungal agent.
General Description
1-(Triphenylmethyl)imidazole is an imidazole derivative.
Synthesis
288-32-4
76-83-5
15469-97-3
The reaction was carried out in a 50 L autoclave using imidazole (880 g, 12.9 mol, 1.0 eq.) and triphenylchloromethane (3605.0 g, 12.9 mol, 1.0 eq.) as raw materials. First, imidazole was dissolved in 12 L of DMF and cooled to below 0 °C. Subsequently, triethylamine (1308 g, 12.9 mol, 1.0 eq.) was added and the reaction was kept for 30 min. A DMF solution of triphenylchloromethane (16 L) was slowly added dropwise to the reaction mixture at 0°C. After the dropwise addition was completed, the reaction system was warmed to 15°C and the reaction was continued with stirring for 16 hours. Upon completion of the reaction, the reaction mixture was poured into water and a large amount of solid was precipitated. The solid was collected by filtration and the filter cake was washed with water, drained and dried to afford N-trityl imidazole (Compound XIV-1) as a white solid 3835.1 g in 95.6% yield.
References
[1] Patent: CN104086553, 2016, B. Location in patent: Paragraph 0065-0068
[2] Patent: US2010/16610, 2010, A1. Location in patent: Page/Page column 28
[3] Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 253 - 256
[4] Tetrahedron, 1999, vol. 55, # 13, p. 4109 - 4122
[5] Patent: US6476216, 2002, B1
1-(Triphenylmethyl)imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(Triphenylmethyl)imidazole manufacturers
- Product
- 1-(Triphenylmethyl)imidazole 15469-97-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-18