ChemicalBook > CAS DataBase List > 2-Chloro-5-methylsulfanylbenzoic acid

2-Chloro-5-methylsulfanylbenzoic acid

Product Name: 2-Chloro-5-methylsulfanylbenzoic acid
CAS No.: 51546-12-4
Chemical Name: 2-Chloro-5-methylsulfanylbenzoic acid
Synonyms: TOME-1;LABOTEST-BB LT00452880;Gene-rich cluster protein C8;Trigger of mitotic entry protein 1;2-CHLORO-5-(METHYLTHIO)BENZOIC ACID;2-Chloro-5-methylsulfanylbenzoicaci;2-CHLORO-5-METHYLSULFANYLBENZOIC ACID;Benzoic acid, 2-chloro-5-(methylthio)-;Cell division cycle-associated protein 3;2-CHLORO-5-(METHYLTHIO)BENZOIC ACID TECH 98.0%
CBNumber: CB2228534
Molecular Formula: C8H7ClO2S
Formula Weight: 202.66
MOL File: 51546-12-4.mol

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2-Chloro-5-methylsulfanylbenzoic acid Property

Melting point:: 136-137 °C (lit.)
Boiling point:: 342.4±32.0 °C(Predicted)
Density: 1.42
storage temp.: Sealed in dry,Room Temperature
pka: 2.74±0.25(Predicted)
form: solid
Appearance: White to off-white Solid
biological source: rabbit

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 245380
Product name: 2-Chloro-5-(methylthio)benzoic acid
Purity: technical grade, 96%
Packaging: 10g
Price: $214.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: SAB4503278
Product name: Anti-CDCA3, C-Terminal antibody produced in rabbit
Purity: affinity isolated antibody
Packaging: 100μG
Price: $485
Updated: 2023/01/07

Sigma-Aldrich

Product number: 245380
Product name: 2-Chloro-5-(methylthio)benzoic acid
Purity: technical grade, 96%
Packaging: 50g
Price: $600
Updated: 2023/01/07

TRC

Product number: C587598
Product name: 2-Chloro-5-(methylthio)benzoic acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6666-5-X1
Product name: 2-Chloro-5-(methylthio)benzoic acid, tech
Packaging: 5G
Price: $42
Updated: 2021/12/16

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2-Chloro-5-methylsulfanylbenzoic acid Chemical Properties,Usage,Production

Uses

2-Chloro-5-(methylthio)benzoic acid may be used in chemical synthesis studies.

Synthesis

886973-19-9

544-92-3

127510-97-8

51546-12-4

Methyl 2-chloro-5-(methylthio)benzoate (23.2 g, 106.9 mmol) and cuprous cyanide (19.2 g, 213.8 mmol) were dissolved in 100 mL of N-methylpyrrolidone. The reaction mixture was heated at 160 °C for 72 hours. The progress of the reaction was monitored by LCMS, which showed the presence of cyanide ester and hydrolyzed acid in a 1:1 ratio. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently treated with 250 mL of water and 300 mL of ethyl acetate and filtered through diatomaceous earth. After separating the organic and aqueous phases, the aqueous phase was extracted with 2 x 250 mL of ethyl acetate. The organic phases were combined, washed with 250 mL of water, dried over MgSO4 and concentrated to give an oily crude product. The crude product was purified by combi fast silica gel column chromatography using a hexane solution of 0-20% ethyl acetate as eluent, resulting in methyl 2-cyano-5-(methylthio)benzoate (6.14 g, 28% yield) as a white solid.The LCMS analysis showed the following: retention time (Rt) = 2.42 min; mass-to-charge ratio (m/z) [M + H]+ = 208.

References

[1] Patent: WO2006/67462, 2006, A1. Location in patent: Page/Page column 61

2-Chloro-5-methylsulfanylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-5-methylsulfanylbenzoic acid manufacturers

Career Henan Chemical Co

Product: 2-Chloro-5-methylsulfanylbenzoic acid 51546-12-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-17

Nanjing jinheyou Trading Co., Ltd.

Product: 2-Chloro-5-methylsulfanylbenzoic acid 51546-12-4
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 20kg/month
Release date: 2019-11-05

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