Molsidomine

Product Name: Molsidomine
CAS No.: 25717-80-0
Chemical Name: Molsidomine
Synonyms: SIN-10;Coruno;morial;CAS 276;CORVATON;corvasal;Corraton;MOTAZOMIN;SydnopharM;molsidolat
CBNumber: CB2234645
Molecular Formula: C9H14N4O4
Formula Weight: 242.23
MOL File: 25717-80-0.mol

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Molsidomine Property

Melting point:: 140-141°C
Boiling point:: 385.05°C (rough estimate)
Density: 1.3186 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride.
pka: pK (100°) 3.0 ± 0.1
form: Solid
color: White to Off-White
λmax: 317nm(MeOH)(lit.)
Merck: 14,6234
CAS DataBase Reference: 25717-80-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: WU7677400
HS Code: 29349990
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M2901
Product name: Molsidomine
Packaging: 500mg
Price: $91.1
Updated: 2023/01/07

Sigma-Aldrich

Product number: M2901
Product name: Molsidomine
Packaging: 5g
Price: $522
Updated: 2023/01/07

TCI Chemical

Product number: M2524
Product name: Molsidomine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $48
Updated: 2024/03/01

TCI Chemical

Product number: M2524
Product name: Molsidomine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $141
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000821
Product name: Molsidomine
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000821
Price: $150
Updated: 2024/03/01

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Molsidomine Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Corvasal,Hoechst

Uses

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.

Definition

ChEBI: 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate is a member of morpholines.

Manufacturing Process

1.6 parts by volume of ethyl chloroformate is stirred dropwise into a suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in 5 parts by volume of pyridine, and the mixture is agitated for a while to allow reaction to take place. Pyridine is removed from the reaction mixture by evaporation, and the residue is dissolved in a small amount of water and extracted with chloroform several times. The extract is dehydrated by adding anhydrous magnesium sulfate and subjected to filtration. Chloroform is removed from the filtrate by distillation, crude crystals being obtained. Recrystallization of the crude crystals from toluene gives 0.6 part by weight of 3-morpholino-N-carboethoxysydnonimine having a melting point of 140°- 141°C. Yield 51%.

brand name

Corvaton (Hoechst-Roussel).

Therapeutic Function

Coronary vasodilator

Molsidomine Preparation Products And Raw materials

Raw materials

N-Aminomorpholine Ethyl chloroformate POTASSIUM CYANIDE

Preparation Products

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Molsidomine Suppliers

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View Lastest Price from Molsidomine manufacturers

airuikechemical co., ltd.

Product: molsidomine 25717-80-0
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

Hebei Weibang Biotechnology Co., Ltd

Product: Molsidomine 25717-80-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: Molsidomine 25717-80-0
Price: US $10.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-14

25717-80-0, MolsidomineRelated Search:

Ethanol CHLOROETHANE 1-(2,6-Dimethylphenoxy)-2-propanamine Ethylparaben Tris(trimethylsilyl)phosphate Ethyl cellulose Ethylbenzene Ethyl acrylate Ethyl formate Ethyl acetate Diethyl ether 3-MORPHOLINOSYDNONIMINE 4-AMINO-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE/ MOLSIDOMINE Molsidomine impurity B Molsidomine impurity D Molsidomine MOLSIDOMINE IMP. B (PHARMEUROPA): 4-NITROSOMORPHOLINE MOLSIDOMINE IMP. A (PHARMEUROPA) AS HYDROCHLORIDE:3-(MORPHOLIN-4-YL)SYDNONIMINE HYDROCHLORIDE (LINSIDOMINE HYDROCHLORIDE)

ethyl (3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)aminoformate

CORVATON

N-Carboxy-3-morpholino-syndone imine ethyl ester

corvasal

SIN-10

n-carboxy-3-morpholinosynonimine ethyl ester

N-(ETHOXYCARBONYL)-3-(4-MORPHOLINO)SYDNONE IMINE

N-[ETHOXYCARBONYL]-3-[4-MORPHOLINYL]SYDNONE IMINE

MOTAZOMIN

MORSIDOMINE

MORSYDOMINE

MOLSIDOMINE

5-[(Ethoxycarbonyl)aMino]-3-(4-Morpholinyl)-1,2,3-oxadiazoliuM Inner Salt

CAS 276

Corraton

Coruno

N-(Ethoxycarbonyl)-3-Morpholinosydnone iMine

SIN 10 (pharMaceutical)

SydnopharM

Molsidomine, 98%, Guanylate cyclase activator

N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10

1-Ethoxy-N-(3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)methanimidate

5-Ethoxycarbonyl-3-morpholinosydnonimine

N-(Ethoxycarbonyl)-3-(4-morpholino)syndone imine

N-Ethoxycarbonyl-3-morphalinosydnomine

(1E)-1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate

molsidolat

morial

n-(ethoxycarbonyl)-3-(4-morpholinyl)-sydnoneimin

n-carboxy-3-morpholino-sydnoneiminethylester

n-carboxy-3-morpholinosydnonimineethylester

n-ethoxycarbonyl-3-morpholinosydnonimine

Molsidomine&gt

Molsidomine CRS

Molsidomine USP/EP/BP

(Ethoxycarbonyl)(3-morpholino-1,2,3-oxadiazol-3-ium-5-yl)amide

Molsidomine, ≥ 98.0%

25717-80-0

C9H14N4O4

Nitric Oxide Metabolism

NO Donors

Cell Signaling Enzymes

Biochemicals and Reagents

Application Index

BioChemical

Enzymes, Inhibitors, and Substrates

Nitric Oxide

API