ChemicalBook > CAS DataBase List > Ethyl bromodifluoroacetate
Ethyl bromodifluoroacetate
- Product Name
- Ethyl bromodifluoroacetate
- CAS No.
- 667-27-6
- Chemical Name
- Ethyl bromodifluoroacetate
- Synonyms
- 2-broMo-2,2-difluoroacetate;EBDA;2-Bromo-2,2-difluoroacetic acid ethyl ester;EBFA;bromodifL;Ethyl bromodifluoroa;Ethylbromdifluoracetat;Twoethyl broMidefluoride;ETHYL BROMODIFLUOROACETATE;difluorobromo ethyl acetate
- CBNumber
- CB2238865
- Molecular Formula
- C4H5BrF2O2
- Formula Weight
- 202.98
- MOL File
- 667-27-6.mol
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Ethyl bromodifluoroacetate Property
- Boiling point:
- 112 °C/700 mmHg (lit.)
- Density
- 1.583 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.387(lit.)
- Flash point:
- 70 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in most organic solvents.
- form
- Liquid
- color
- Clear colorless to slightly yellow
- Specific Gravity
- 1.583
- BRN
- 1906095
- InChI
- InChI=1S/C4H5BrF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
- InChIKey
- IRSJDVYTJUCXRV-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C(Br)(F)F
- CAS DataBase Reference
- 667-27-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethyl bromodifluoroacetate(667-27-6)
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Safety
- Hazard Codes
- C,F,Xi
- Risk Statements
- 10-34-36
- Safety Statements
- 26-36/37/39-45-16-27
- RIDADR
- UN 2924 3/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant/Flammable
- TSCA
- No
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29159000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 295795
- Product name
- Ethyl bromodifluoroacetate
- Purity
- 98%
- Packaging
- 5g
- Price
- $72.2
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B1463
- Product name
- Ethyl Bromodifluoroacetate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $20
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B1463
- Product name
- Ethyl Bromodifluoroacetate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $53
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- B20461
- Product name
- Ethyl bromodifluoroacetate, 97%
- Packaging
- 5g
- Price
- $65.65
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B1463
- Product name
- Ethyl Bromodifluoroacetate
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $306
- Updated
- 2024/03/01
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Ethyl bromodifluoroacetate Chemical Properties,Usage,Production
Description
Ethyl bromodifluoroacetate, a clear to yellow liquid, is an ester of bromodifluoroacetic acid and ethyl alcohol. It is an ester that can be used to introduce the CF2 group when synthesizing chemical compounds. Ethyl bromdifluoroacetate is considered to be a good compound in the generation of compounds and for testing with other organic compounds like lactones, imines, and other amino acids.
Chemical Properties
clear colorless to slightly yellow liquid
Uses
Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.
Uses
Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis. A Cu-catalyzed regioselective bromodifluoroacetylation of alkenes, using ethyl bromodifluoroacetate (BrCF2CO2Et) as a difluoroacetylating reagent.
Uses
Ethyl bromodifluoroacetate is usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives.
Preparation
Difluorobromoacetonitrile is taken as a raw material, and prepared through a one-pot method and subjected to alcoholysis and esterification in ethanol aqueous solution to obtain ethyl bromodifluoroacetate.Reaction equation is:
BrF2CCN→BrF2CCOOH→BrF2CCOOC2H5
Ethyl bromodifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl bromodifluoroacetate manufacturers
Hebei Weibang Biotechnology Co., Ltd
- Product
- Ethyl bromodifluoroacetate 667-27-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- Ethyl bromodifluoroacetate 667-27-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-08-23
Career Henan Chemical Co
- Product
- Ethyl bromodifluoroacetate 667-27-6
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21
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