Fenbufen

Product Name: Fenbufen
CAS No.: 36330-85-5
Chemical Name: Fenbufen
Synonyms: bufemid;cl82204;napanol;cinopal;Cinopol;enbufen;lederfen;FENBUFEN;Fenbufen CRS;FENBUFENTABLETS
CBNumber: CB2239125
Molecular Formula: C16H14O3
Formula Weight: 254.29
MOL File: 36330-85-5.mol

More

Less

Fenbufen Property

Melting point:: 184-187 °C (lit.)
Boiling point:: 357.5°C (rough estimate)
Density: 1.1565 (rough estimate)
refractive index: 1.5600 (estimate)
storage temp.: 2-8°C
solubility: Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride.
pka: pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain)
form: Solid
color: White to off-white
Water Solubility: 2.212mg/L(25 ºC)
Merck: 13,3990
EPA Substance Registry System: [1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo- (36330-85-5)

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 28-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DV1761000
HazardClass: 6.1
PackingGroup: III
HS Code: 2918300090
Toxicity: LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BP354
Product name: Fenbufen
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $257
Updated: 2024/03/01

Sigma-Aldrich

Product number: F8755
Product name: Fenbufen
Purity: analytical standard
Packaging: 5g
Price: $110
Updated: 2022/05/15

Alfa Aesar

Product number: H60557
Product name: 4-(4-Biphenylyl)-4-oxobutyric acid, 96%
Packaging: 1g
Price: $45.65
Updated: 2024/03/01

Alfa Aesar

Product number: H60557
Product name: 4-(4-Biphenylyl)-4-oxobutyric acid, 96%
Packaging: 5g
Price: $151.65
Updated: 2024/03/01

Cayman Chemical

Product number: 28851
Product name: Fenbufen
Packaging: 5g
Price: $93
Updated: 2024/03/01

More

Less

Fenbufen Chemical Properties,Usage,Production

Description

Fenbufen has been found to be an effective, well-tolerated drug for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene) acylation of biphenyl with succinic anhydride. The compound is metabolized in humans first to 4-hydroxy-4-biphenylbutyric acid (tmax 2.5 h) then to 4-biphenyl acetic acid (tmax 7.5 h). Both metabolites are more active than fenbufen itself and circulate for several hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively long plasma half-lives allows for once a day dosing with this agent.

Chemical Properties

White Solid

Originator

Cinopal,Cyanamid,Italy,1976

Uses

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory

Uses

muscle relaxant (smooth)

Definition

ChEBI: Fenbufen is a member of biphenyls and a 4-oxo monocarboxylic acid. It has a role as a non-steroidal anti-inflammatory drug.

Manufacturing Process

135 g of aluminum chloride is dissolved in 500 ml of nitrobenzene, the solution being held below 10°C by external cooling. A finely ground mixture of 50 g of succinic anhydride and 75 g of biphenyl is added to the stirred solution, the temperature being held below 10°C. It is then held at room temperature for four days. After pouring the reaction mixture into a solution of 150 ml of concentrated hydrochloric acid in 1 liter of ice water, the nitrobenzene is removed by steam distillation. The solid is collected, dissolved in 4 liters of 3% hot sodium carbonate solution, clarified, and reprecipitated by the addition of excess 6N sulfuric acid solution. The crude product is collected, dried, and recrystallized from ethanol to give the pure subject compound, MP 185°C to 187°C.

Therapeutic Function

Antiinflammatory

General Description

Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.

Trade name

Clincopal (Lederle, Spain), Lederfen (Lederle, UK), Napanol (Lederle, Japan).

Safety Profile

Poison by ingestion,intraperitoneal, and subcutaneous routes. Human systemiceffects by ingestion: cough, sweating, body temperature.An experimental teratogen. Other experimentalreproductive effects. An anti-inflammatory agent. Whenheated to decomposi

Fenbufen Preparation Products And Raw materials

Raw materials

Biphenyl Succinic anhydride

Preparation Products

More

Less

Fenbufen Suppliers

Belgium 1 Canada 1 China 198 Germany 2 India 10 South Korea 1 Switzerland 3 United Kingdom 5 United States 34 Venezuela 1 Global 256

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Olinax Inc.

Tel: --
Fax: --
Email: info@olinax.com
Country: United States
ProdList: 404
Advantage: 50

HBCChem Inc.

Tel: --
Fax: --
Email: sales@hbcchem-inc.com
Country: United States
ProdList: 4569
Advantage: 30

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Selleck Chemicals LLC

Tel: --
Fax: --
Email: sales@selleckchem.com
Country: United States
ProdList: 1848
Advantage: 58

Rieke Metals, Inc.

Tel: --
Fax: --
Email: sales@riekemetals.com
Country: United States
ProdList: 6509
Advantage: 69

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Heterocyclics Inc

Tel: --
Fax: --
Email: info@heterocyclics.com
Country: United States
ProdList: 1669
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Altan Corporation

Tel: --
Fax: --
Email: OrderingService@AltanBiochemicals.com
Country: United States
ProdList: 1161
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

ASDI Incorporated

Tel: --
Fax: --
Email: customerservice@asdi.net
Country: United States
ProdList: 6922
Advantage: 67

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

More

Less

View Lastest Price from Fenbufen manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-(4-Biphenyl)-4-oxobutyric acid 36330-85-5
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-20

Liaoning Pharmaceutical Innovation Co., Ltd

Product: Fenbufen 36330-85-5
Price: US $100.00-1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-03-06

Xiamen Wonderful Bio Technology Co., Ltd.

Product: fenbufen 36330-85-5
Price: US $66.00/KG
Min. Order: 1250KG
Purity: 99%
Supply Ability: 330T
Release date: 2023-07-21

36330-85-5, FenbufenRelated Search:

FIREMASTER BP-6 2-Oxo-4-phenylbutyric acid Ethyl acetoacetate Bifonazole trans-Bifenthtin 2-Oxobutyric acid Butyrophenone 2,3,3',4,4',5-HEXACHLOROBIPHENYL Biphenyl Bifendate Carbonyl iron powder FENBUFEN Tanomastat ETHYL 4-(4-BIPHENYL)-4-OXOBUTYRATE flobufen Fenbufen-d9 Α-KETOBUTYRIC ACID Fenbufen

FENBUFEN

GAMMA-OXO-[1,1'-BIPHENYL]-4-BUTANOIC ACID

GAMMA-OXO(1,1'-BIPHENYL)-BUTANOIC ACID

4-(4-BIPHENYL)-4-OXOBUTYRIC ACID

4-(4-BIPHENYLYL)-4-OXOBUTYRIC ACID

3-(4-PHENYLBENZOYL)PROPIONIC ACID

cl82204

diphenyl-4-gamma-oxo-gamma-butyricacid

lederfen

napanol

[1,1'-Biphenyl]-4-butanoic acid, γ-oxo

1’-biphenyl)-4-butanoicacid,gamma-oxo-(

3-(4-biphenylylcarbonyl)-propionicaci

3-(4-biphenylylcarbonyl)propionicacid

beta,p-phenylbenzoylpropionicacid

bufemid

butyricacid4-(4-biphenyl)-4-oxo-

cinopal

3-[4-Biphenylcarbonyl] propionic acid

γ-oxo-(1,1'-biphenyl)-4-butanoic acid

diphenyl acetoacetate

gamma-oxo-(1'-biphenyl)-4-butanoic acid

[1,1'-biphenyl]-4-butanoic Acid.

4-(Biphenyl-4-yl)-4-oxobutanoic Acid

Cinopol

γ-Oxo[1,1'-biphenyl]-4-butyric acid

3-(4-Phenylbenzoyl)propionic

4-(4-Phenylphenyl)-4-oxobutyric acid

enbufen

Fenchlorphos`Fenbufen

JRH-05504, 3-(4-Phenyl)benzoyl propionic acid, 97%

Fenbufen,Sulindac,Naproxen,Probenecid

FENBUFENTABLETS

Fenbufen CRS

Pyrido[2,3-d]pyrimidine-6-carboxylicacid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-, hydrate (1:3)

Fenbufen USP/EP/BP

Finn cloth Finn

3-(p-phenyl)benzoylpropionic acid

4-([1,1'-Biphenyl]-4-yl)-4-oxobutanoic acid

36330-85-5

C6H5C6H4COCH22CO2H

25428

Organic Building Blocks

FA - FL

Alphabetic

Carbonyl Compounds

Carboxylic Acids

C13 to C42+

Analytical Chromatography Product Catalog

Analytical Standards

Building Blocks

COLOFAC

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals