Ethyl 2-acetyl-3-(dimethylamino)acrylate
- Product Name
- Ethyl 2-acetyl-3-(dimethylamino)acrylate
- CAS No.
- 51145-57-4
- Chemical Name
- Ethyl 2-acetyl-3-(dimethylamino)acrylate
- Synonyms
- Leflunomide Impurity 8;ETHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE;Ethyl2-acetyl-3-(dimethylamino)acrylate,95%;ethyl (2z)-2-acetyl-3-(dimethylamino)acrylate;ETHYL N, N-DIMETHYLAMINOMETHYLENE ACETOACETATE;Ethyl 2-[(dimethylamino)methylene]acetoacetate;2-ACETYL-3-DIMETHYLAMINO-ACRYLIC ACID ETHYL ESTER;ethyl 2-[(diMethylaMino)Methylidene]-3-oxobutanoate;Ethyl 2-[(dimethylamino)methylene]-3-oxo-Butanoicate;(E)-ethyl 2-((diMethylaMino)Methylene)-3-oxobutanoate
- CBNumber
- CB2239716
- Molecular Formula
- C9H15NO3
- Formula Weight
- 185.22
- MOL File
- 51145-57-4.mol
Ethyl 2-acetyl-3-(dimethylamino)acrylate Property
- Melting point:
- 41-44 °C(Solv: isopropyl ether (108-20-3))
- Boiling point:
- 128°C 0,2mm
- Density
- 1.038±0.06 g/cm3(Predicted)
- refractive index
- 1.5330-1.5370
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 3.52±0.70(Predicted)
- form
- Liquid
- color
- Pale red
- λmax
- 304nm(EtOH(95vol%))(lit.)
- CAS DataBase Reference
- 51145-57-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/37/38-34
- Safety Statements
- 26-36/37/39-45-23
- RIDADR
- UN2735
- HazardClass
- IRRITANT
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E1179
- Product name
- Ethyl 2-Acetyl-3-(dimethylamino)acrylate
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- E1179
- Product name
- Ethyl 2-Acetyl-3-(dimethylamino)acrylate
- Purity
- >95.0%(GC)(T)
- Packaging
- 25g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- E916625
- Product name
- Ethyl2-Dimethylaminomethylene-3-oxobutanoate
- Packaging
- 250g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- OR23897
- Product name
- Ethyl2-[(dimethylamino)methylene]acetoacetate
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4329-1-X2
- Product name
- Ethyl 2-[(dimethylamino)methylene]acetoacetate
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
Ethyl 2-acetyl-3-(dimethylamino)acrylate Chemical Properties,Usage,Production
Chemical Properties
Yellow Oil
Uses
Ethyl 2-Dimethylaminomethylene-3-oxobutanoate (cas# 51145-57-4) is a compound useful in organic synthesis.
Synthesis
141-97-9
4637-24-5
134653-70-6
The general procedure for the synthesis of ethyl (Z)-2-((dimethylamino)methylene)-3-oxobutanoate from ethyl acetoacetate and N,N-dimethylformamide dimethyl acetal was as follows: referring to Example 75, ethyl acetoacetate (79 mL, 0.62 mol) was added to N,N-dimethylformamide dimethyl acetal (100 mL, 0.68 mol) and the mixture was heated to reflux for 1 hour. Upon completion of the reaction, the excess acetal was removed by subtractive distillation, followed by subtractive distillation of the residue to afford the target product (Z)-ethyl (Z)-2-((dimethylamino)methylene)-3-oxobutanoate (85 g, 74% yield). The boiling point of the product was 125-130 °C (400 Pa).1H-NMR (CDCl3) δ: 1.33 (3H, t, J = 7.1 Hz), 2.33 (3H, s), 3.04 (6H, br s), 4.23 (2H, q, J = 7.1 Hz), 7.68 (1H, s).
References
[1] Patent: WO2006/73361, 2006, A1. Location in patent: Page/Page column 147
[2] Patent: US2007/244088, 2007, A1. Location in patent: Page/Page column 38
[3] Patent: US2008/9523, 2008, A1. Location in patent: Page/Page column 18; 19
[4] Patent: WO2008/4943, 2008, A1. Location in patent: Page/Page column 59
[5] Patent: WO2008/4942, 2008, A1. Location in patent: Page/Page column 56
Ethyl 2-acetyl-3-(dimethylamino)acrylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-acetyl-3-(dimethylamino)acrylate Suppliers
- Tel
- --
- Fax
- --
- sales@advamacs.com
- Country
- Poland
- ProdList
- 602
- Advantage
- 58
View Lastest Price from Ethyl 2-acetyl-3-(dimethylamino)acrylate manufacturers
- Product
- Ethyl 2-acetyl-3-(dimethylamino)acrylate 51145-57-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-11
- Product
- Ethyl 2-acetyl-3-(dimethylamino)acrylate 51145-57-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-14