Cycloastragenol
- Product Name
- Cycloastragenol
- CAS No.
- 78574-94-4
- Chemical Name
- Cycloastragenol
- Synonyms
- Cyclosieversigenin;Cyclogalegenol;purity;cycloastragenol;Astramembrangenin;CYCLOASTRAGENOL(SH);Cycloastragenol Powder;Astragalus Root Extract Cycloastragenol;Cycloastragenol, 98%, from Astragalus membranaceus Bunge;Cycloastragenol（Cyclosiversigenin,Astramembrangenin,Cyclosieversigenin）
- CBNumber
- CB22457569
- Molecular Formula
- C30H50O5
- Formula Weight
- 490.72
- MOL File
- 78574-94-4.mol
Cycloastragenol Property
- Melting point:
- 241.0 to 245.0 °C
- Boiling point:
- 617.2±55.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, first dissolve in DMF and then dilute with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method.Solubility in DMSO is 98 mg/mL (199.7 mM)
- form
- powder to crystal
- pka
- 14.57±0.29(Predicted)
- color
- White to Almost white
- InChI
- InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22-,23-,26+,27-,28+,29-,30+/s3
- InChIKey
- WENNXORDXYGDTP-XWIGRFCYNA-N
- SMILES
- [C@@]1(C)(O[C@H](CC1)C(C)(C)O)[C@@]1([H])[C@@H](O)C[C@]2(C)[C@]1(C)CC[C@@]13C[C@@]41[C@@]([H])([C@@H](O)C[C@]32[H])C(C)(C)[C@@H](O)CC4 |&1:0,3,10,12,15,17,21,23,24,26,29,34,r|
Safety
- RTECS
- GX8265000
- HS Code
- 2932.19.5100
N-Bromosuccinimide Price
- Product number
- PHL82509
- Product name
- Cycloastragenol
- Purity
- phyproof?ReferenceSubstance
- Packaging
- 10mg
- Price
- $480
- Updated
- 2024/03/01
- Product number
- C3469
- Product name
- Cycloastragenol
- Packaging
- 25mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- C3469
- Product name
- Cycloastragenol
- Packaging
- 100mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- C987618
- Product name
- Cycloastragenol
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 36989
- Product name
- Cycloastragenol,≥99%(HPLC)
- Purity
- ≥99%(HPLC)
- Packaging
- 5G
- Price
- $946.4
- Updated
- 2021/12/16
Cycloastragenol Chemical Properties,Usage,Production
Description
Cycloastragenol is the genuine sapogenin of astragaloside IV, a major bioactive constituent of the Chineseherbal medicine Astragali Radix (Huang-Qi). Astragaloside IV exhibits various pharmacological properties, suchas anti-viral, anti-inflammatory, anti-aging,and antioxidant activities.Cycloastragenol is a telomerase activator,which delays the onset of cellularaging. Thus, cycloastragenol is considered as a newgeneration of anti-aging agent.
Uses
Cycloastragenol, a saponin and aglycone found in Astragalus, is a natural triterpenoid. It has anti-aging properties and can also act as an adjuvant therapy for cancer by enhancing the effectiveness of anti-cancer drugs, reducing their toxicity, and preventing/treating leukopenia caused by these treatments.
Definition
ChEBI: Cycloastragenol is a sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus. It has a role as a metabolite. It is a sapogenin, a pentacyclic triterpenoid, a tetrol and a member of oxolanes. It derives from a hydride of a 5alpha-gonane.
Preparation
The cycloastragenol was prepared by acid hydrolysis, and the oxidation reaction was carried out before the hydrolysis. The technological process is: oxidation-reduction-hydrolysis-extraction.
benefits
Cycloastragenol has a steroidal skeleton of tetracyclic triterpene and possess diverse pharmacological activities such as anti-aging, anti-inflammatory, anti-fibrosis, pro-wound healing, liver protection and endothelial protection.
A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications
Biological Activity
Cycloastragenol(78574-94-4), a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation [1]. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro [3]. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4 [2].
Biochem/physiol Actions
Cycloastragenol is used as a nutraceutical (e.g. TAT2) and seems to moderately increase the telomerase activity and proliferative capacity of both CD4 and CD8 T-cells. Cycloastragenol possesses antiviral, antimicrobial, anti-inflammatory, anti-hepatotoxic, anti-leukemia, antitumor and antinociceptive activity. It also acts as an immunomodulator.
Side effects
Cycloastragenol is a telomerase activator. Fortunately, the experimental results did not show an increased risk of cancer and other adverse effects.
Source
Cycloastragenol is isolated from Astragalus species.
Dosage
As a dietary supplement, take one 100mg capsule of Cycloastragenol daily.
References
[1]. Jing Zhu, et al. In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator. Drug Metabolism and PharmacokineticsVolume 25, Issue 5, 2010, Pages 477-486
[2]. WEI Bao-hong, et al. Effect of continuous oral cycloastragenol on the activity of cytochrome P450 enzymes in rats. Chinese New Drugs Journal, 2014 -04
[3]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.
Cycloastragenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cycloastragenol manufacturers
- Product
- Cycloastragenol Powder 78574-94-4
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-18
- Product
- Cycloastragenol 78574-94-4
- Price
- US $0.00-0.00/G
- Min. Order
- 100G
- Purity
- 98% up, High Density
- Supply Ability
- 20 tons
- Release date
- 2024-06-27
- Product
- Cycloastragenol 78574-94-4
- Price
- US $260.00-22480.00/g
- Min. Order
- 10g
- Purity
- 1%-99%
- Supply Ability
- 1000kg
- Release date
- 2024-09-20