ChemicalBook > CAS DataBase List > N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide

N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide

Product Name: N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide
CAS No.: 1201645-46-6
Chemical Name: N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide
Synonyms: 5-Acetamidopyridine-3-boronicacidpinacolester,98%;N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl);5-(Acetamido)pyridine-3-boronic acid pinacol ester;(5-ACETAMIDOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;5-N-Acetyl-amino-pyridin-3-ylboronic acid pinacol ester;N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide;N-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-acetamide;Acetamide, N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-;N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide 95%min
CBNumber: CB22499767
Molecular Formula: C13H19BN2O3
Formula Weight: 262.11
MOL File: 1201645-46-6.mol

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N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide Property

Boiling point:: 441.8±30.0 °C(Predicted)
Density: 1.11±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
pka: 14.30±0.70(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 1201645-46-6

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: T890035
Product name: N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide
Packaging: 100mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: Z3966
Product name: N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide
Packaging: 250mg
Price: $211
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0007285
Product name: N-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL)ACETAMIDE
Purity: 95.00%
Packaging: 1G
Price: $638.4
Updated: 2021/12/16

AK Scientific

Product number: Z3966
Product name: N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide
Packaging: 100mg
Price: $158
Updated: 2021/12/16

AK Scientific

Product number: Z3966
Product name: N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide
Packaging: 5g
Price: $1253
Updated: 2021/12/16

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N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide Chemical Properties,Usage,Production

Synthesis

15862-46-1

73183-34-3

1201645-46-6

General procedure: 3-acetamido-5-bromopyridine (0.23 mol, 58.42 g), bis(pinacolato)diboron (0.23 mol, 58.42 g) and potassium acetate (0.69 mol, 67.62 g) were added sequentially to a 1 L four-necked round-bottomed flask equipped with a magnetic stirrer, a thermometer, a reflux condenser and a nitrogen bulb apparatus, followed by 450 mL of dioxane as solvent. Ferrocene palladium chloride (0.0051 mol, 3.80 g) was added to the reaction system as a catalyst under nitrogen protection. The reaction mixture was heated to 100 °C and the reaction was stirred at this temperature for 18-24 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. After completion of the reaction, it was cooled to room temperature and the precipitated solid was separated by pulping and filtration. The solid was dissolved in 500 mL of methanol, filtered and the solvent was evaporated to dryness. Finally, heptane was added for pulping to obtain the target product 3-acetamido-pyridine-5-boronic acid pinacol ester 55.40 g in 92.1% yield.

References

[1] Patent: CN103601745, 2017, B. Location in patent: Paragraph 0037; 0038
[2] Patent: WO2014/140077, 2014, A1. Location in patent: Page/Page column 55-56
[3] Patent: WO2009/155527, 2009, A2. Location in patent: Page/Page column 254

N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide Suppliers

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1201645-46-6, N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamideRelated Search:

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N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide

N-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-acetamide

5-(Acetamido)pyridine-3-boronic acid pinacol ester

N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)

(5-ACETAMIDOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER

Acetamide, N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-

5-Acetamidopyridine-3-boronicacidpinacolester,98%

5-N-Acetyl-amino-pyridin-3-ylboronic acid pinacol ester

N-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)acetamide 95%min

1201645-46-6