ChemicalBook > CAS DataBase List > 2'-deoxy-2'-fluoro-2'-C-methylcytidine

2'-deoxy-2'-fluoro-2'-C-methylcytidine

Product Name
2'-deoxy-2'-fluoro-2'-C-methylcytidine
CAS No.
817204-33-4
Chemical Name
2'-deoxy-2'-fluoro-2'-C-methylcytidine
Synonyms
ethyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxylate;PSI 6130;R 1656;CS-1995;PSI-6130(R 1656);PSI-6130;PSI 6130;Sofosbuvir Impurity 121;PSI-6130;R 1656;PSI 6130;2'-Deoxy-2'-F-2'-C-methylcytidine;2'-deoxy-2'-Fluoro-2'-methylcytidine
CBNumber
CB22525888
Molecular Formula
C10H14FN3O4
Formula Weight
259.23
MOL File
817204-33-4.mol
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2'-deoxy-2'-fluoro-2'-C-methylcytidine Property

Melting point:
216-218℃
Boiling point:
482.4±55.0 °C(Predicted)
Density 
1.67
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Methanol (Slightly), Water (Slightly)
pka
12.86±0.70(Predicted)
form 
Solid
color 
White to Light Brown
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13575
Product name
PSI-6130
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
13575
Product name
PSI-6130
Packaging
5mg
Price
$321
Updated
2024/03/01
TRC
Product number
P839680
Product name
PSI6130
Packaging
25mg
Price
$640
Updated
2021/12/16
Matrix Scientific
Product number
097930
Product name
4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Purity
95+%
Packaging
1g
Price
$685
Updated
2021/12/16
Biorbyt Ltd
Product number
orb146167
Product name
PSI6130
Purity
>99%
Packaging
1g
Price
$765
Updated
2021/12/16
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2'-deoxy-2'-fluoro-2'-C-methylcytidine Chemical Properties,Usage,Production

Description

PSI-6130 is a nucleoside inhibitor of the NS5B RNA polymerase of hepatitis C virus (HCV; Ki = 4.3 μM). It inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC50s = 0.51 and 0.30 μM, respectively). PSI-6130 also inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC50 values ranging from 0.60 to 1.41 μM, and 0.20 to 0.43 μM, respectively, in the same assay. It has little or no activity against West Nile Virus (WNV), Dengue type 2 virus (DV), human immunodeficiency virus (HIV), or hepatitis B virus (HBV; EC90s = 46.3, >100, >100, and >10 μM, respectively).

Uses

PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.

target

Hepatitis C Virus Nucleoside

2'-deoxy-2'-fluoro-2'-C-methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-deoxy-2'-fluoro-2'-C-methylcytidine Suppliers

China 117 India 1 United Kingdom 1 United States 15 Global 134
AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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United States
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View Lastest Price from 2'-deoxy-2'-fluoro-2'-C-methylcytidine manufacturers

Henan Fengda Chemical Co., Ltd
Product
2'-deoxy-2'-fluoro-2'-C-methylcytidine 817204-33-4
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22
Career Henan Chemical Co
Product
2'-deoxy-2'-fluoro-2'-C-methylcytidine 817204-33-4
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-05

817204-33-4, 2'-deoxy-2'-fluoro-2'-C-methylcytidineRelated Search:

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one 4-Pyridinecarboxamide, 3-chloro-N-methyl- 3-Pyridinecarboxamide, 4-chloro-N-methyl- ((2R,3S,4S)-3-(benzoyloxy)-4-fluoro-4-Methyl-5-oxotetrahydrofuran-2-yl)Methyl benzoate N4-Benzoylcytosine (2R)-2-Deoxy-2-fluoro-2-Methyl-D-erythro-pentonic acid-g-lactone 3,5-bis(4-chlorobenzoate) 2'-C-Methyl-, 2',3',5'-tribenzoateuridine 3-Pyridinecarboxamide, 5-chloro-N-methyl- 2'-deoxy-2'-fluoro-2'-C-methyluridine HUMAN MDC (CCL22) 3-Aminobenzotrifluoride

  • (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Cytidine
  • PSI-6130;R 1656;PSI 6130
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyr
  • R 1656; R-1656; R1656; PSI6130; PSI 6130
  • 2'-deoxy-2'-fluoro-2'-C-methylcytidine
  • PSI 6130
  • R 1656
  • ethyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxylate
  • ethyl 4-broMo-1-Methyl-pyrrole-2-carboxylate
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimi
  • 4-AMino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidin-2(1H)-one
  • 2'-deoxy-2'-fluoro-2'-C-methylcytidin
  • 2'-Deoxy-2'-F-2'-C-methylcytidine
  • CS-1995
  • PSI-6130;PSI 6130
  • Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-
  • 2'-deoxy-2'-fluoro-2'-C-methylcytidine,817204-33-4
  • 2'-deoxy-2'-Fluoro-2'-methylcytidine
  • 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one (sofosbuvir Impurity)
  • Sofosbuvir Impurity 121
  • 2'-C-methyl-2'-Fluoro-2'-deoxyCytidine
  • 2'-Deoxy-2'-fluoro-2'-C-methylcytidine
  • PSI-6130(R 1656)
  • 817204-33-4
  • apis