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Tylvalosin tartrate

Product Name
Tylvalosin tartrate
CAS No.
63428-13-7
Chemical Name
Tylvalosin tartrate
Synonyms
Tylvalosin Tartrate;Acetylisovaleryltylosin Tartrate;Acetylisovaleryltylosin Tartrat;Tylosin, 3-acetate 4B-(3-methylbutanoate), (2R,3R)-2,3-dihydroxybutanedioate (salt);Aivlosin Tartrate;Tawanthin tartrate;TYLVALOSIN TARTRATE PREMIX;Acetylisovalerylosin tartrate;Tylosin 3-acetate 4B-(3-methylbutanoate) (2R,3R)-2,3-dihydroxybutanedioate;TIANFU-CHEM Tylosin 3-acetate 4B-(3-methylbutanoate) (2R,3R)-2,3-dihydroxybutanedioate 63428-13-7
CBNumber
CB22534581
Molecular Formula
C57H93NO25
Formula Weight
1192.35
MOL File
63428-13-7.mol
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Tylvalosin tartrate Property

Melting point:
208 - 211°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
OLLSDNUHBJHKJS-YZBHKUDENA-N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0099515
Product name
Tylvalosintartrate
Packaging
25mg
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
097240
Product name
Acetylisovaleryltylosin tartrate
Purity
80%
Packaging
500mg
Price
$95
Updated
2021/12/16
AK Scientific
Product number
9668AB
Product name
Acetylisovaleryltylosintartrate
Packaging
1g
Price
$145
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0019489
Product name
ACETYLISOVALERYLTYLOSIN TARTRATE
Purity
95.00%
Packaging
1G
Price
$284.55
Updated
2021/12/16
AK Scientific
Product number
J50036
Product name
Acetylisovaleryltylosintartrate,tech.
Packaging
5g
Price
$298
Updated
2021/12/16
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Tylvalosin tartrate Chemical Properties,Usage,Production

Uses

Tylvalosin Tartrate is an impurity of Tylvalosin (T898210); Tylvalosin is an anti-bacterial agent that is shown through study as a good inhibitor of gram-positive bacteria.

Pharmacokinetics

Tylvalosin tartrate is a macrolide antibiotic with antibacterial activity against Gram-positive and some Gram-negative organisms and mycoplasma. It acts by inhibiting protein synthesis in the bacterial cell. Macrolide antibiotics are metabolites or semi-synthetic derivatives of metabolites of soil organisms obtained by fermentation. They have differently-sized lactone rings and are essential due to the dimethylamino group. Tylvalosin has a sixteen-membered ring. Macrolides interfere with protein synthesis by reversibly binding to the 50S ribosome subunit.

Pharmacology

Tylvalosin tartrate is rapidly absorbed after oral administration of Aivlosin. After administration of the recommended dose, lung concentrations of 0.060–0.066 μg/ml were found at 2 and 12 hours post-treatment. The parent compound is widely distributed in the tissues, with the highest concentrations found in the lungs, bile, intestinal mucosa, spleen, kidney, and liver. There is evidence that the concentration of macrolides is higher at the site of infection than in plasma, particularly in neutrophils, alveolar macrophages, and alveolar epithelial cells. In vitro metabolism studies have confirmed that the parent compound is rapidly metabolised to 3-O-acetyltylosin. In a trial with 14C-labeled Aivlosin administered at 2.125 mg/kg to pigs for 7 days, over 70% of the dose was excreted in the feces, with urinary excretion accounting for 3 to 4% of the dose.

in vitro

Tylvalosin tartrate (10 μg/mL; 0.5, 1 h) increases caspase-3 cleavage in porcine neutrophils, leading to DNA fragmentation during apoptosis.Tylvalosin tartrate (0.1-10 μg/mL; 0.5 h) Promote endocytosis of porcine neutrophils by macrophages without changing phagocytosis.

Tylvalosin tartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tylvalosin tartrate manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.
Product
Tylosin 3-acetate 4B-(3-methylbutanoate) (2R,3R)-2,3-dihydroxybutanedioate 63428-13-7
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
10tons
Release date
2024-04-24
Hebei Weibang Biotechnology Co., Ltd
Product
Acetylisovaleryltylosin Tartrate 63428-13-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01
Hebei Yanxi Chemical Co., Ltd.
Product
Tylvalosin tartrate 63428-13-7
Price
US $0.00/kg
Min. Order
1kg
Purity
80% 90%
Supply Ability
20tons
Release date
2023-09-20

63428-13-7, Tylvalosin tartrateRelated Search:


  • Tylosin, 3-acetate 4B-(3-methylbutanoate), (2R,3R)-2,3-dihydroxybutanedioate (salt)
  • Acetylisovaleryltylosin Tartrat
  • Tylosin 3-acetate 4B-(3-methylbutanoate) (2R,3R)-2,3-dihydroxybutanedioate
  • Acetylisovaleryltylosin Tartrate
  • Aivlosin Tartrate
  • Tylvalosin Tartrate
  • (2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6R)-6-(((4R,5S,6S,7R,9R,11E,13E,15R,16R)-4-acetoxy-16-ethyl-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl)oxy)-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (2R,3R)-2,3-dihydroxysuccinic acid
  • (2R,3R,4R,5R,6R)-6-(((2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-(((2S,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-5-Acetoxy-4-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl)methoxy)-4,5-dimethoxy-2-methyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (2R,3R)-2,3-dihydroxysuccinate
  • (2R,3R,4R,5R,6R)-6-(((2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-(((2S,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-5-Acetoxy-4-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-14-hydroxy-5,9,13-trimeth
  • Tylvalosin TartrateQ: What is Tylvalosin Tartrate Q: What is the CAS Number of Tylvalosin Tartrate Q: What is the storage condition of Tylvalosin Tartrate
  • Tawanthin tartrate
  • TIANFU-CHEM Tylosin 3-acetate 4B-(3-methylbutanoate) (2R,3R)-2,3-dihydroxybutanedioate 63428-13-7
  • TYLVALOSIN TARTRATE PREMIX
  • Acetylisovalerylosin tartrate
  • 63428-13-7
  • C53H87NO19xC4H6O6
  • C57H93NO25
  • C53H87NO19C4H6O6
  • API