ChemicalBook > CAS DataBase List > Gefitinib InterMediate B

Gefitinib InterMediate B

Product Name: Gefitinib InterMediate B
CAS No.: 912556-91-3
Chemical Name: Gefitinib InterMediate B
Synonyms: Gefitinib InterMediate B;Gefitinib InterMediate B ISO 9001：2015 REACH;N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-4-quinazolinamine;N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-Methoxyquinazolin-4-aMine;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-;6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine
CBNumber: CB22544180
Molecular Formula: C18H16Cl2FN3O2
Formula Weight: 396.24
MOL File: 912556-91-3.mol

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Gefitinib InterMediate B Property

Melting point:: 234-236 °C
Boiling point:: 523.3±50.0 °C(Predicted)
Density: 1.392±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.40±0.30(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0369686
Product name: N-(3-CHLORO-4-FLUOROPHENYL)-6-(3-CHLOROPROPOXY)-7-METHOXYQUINAZOLIN-4-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $495.2
Updated: 2021/12/16

Matrix Scientific

Product number: 119973
Product name: N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Purity: 95+%
Packaging: 250mg
Price: $706
Updated: 2021/12/16

AK Scientific

Product number: Z5329
Product name: N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Packaging: 1g
Price: $735
Updated: 2021/12/16

Matrix Scientific

Product number: 119973
Product name: N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Purity: 95+%
Packaging: 1g
Price: $1764
Updated: 2021/12/16

Alichem

Product number: 912556913
Product name: N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Packaging: 1g
Price: $749
Updated: 2021/12/16

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Gefitinib InterMediate B Chemical Properties,Usage,Production

Uses

4-Chloro-6-(3-chloropropoxy)-7-methoxyquinazoline is an analogue of Gefitinib, an inhibitor of EGFR with anti-tumor activity.

Synthesis

109-70-6

184475-71-6

912556-91-3

A mixture of 4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol (20.00 g), K2CO3 (10.37 g), KI (1.04 g), 1-bromo-3-chloropropane (7.50 mL), and DMF (150 mL) was stirred and reacted for 6 hours at 40 °C. After completion of the reaction, the reaction mixture was poured into water and the solid was collected by filtration. The filtrate was purified by silica gel column chromatography (eluent: ethyl acetate) to afford the target compound, N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine, as a light yellow liquid (22.05 g, 89.00% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 396.1 ([M+H]+); 1H NMR (400 MHz, CDCl3) δ: 2.01 (m, 2H), 3.68 (t, J=4.2 Hz, 2H), 4.00 (s, 3H), 4.10 (t, J=4.2 Hz, 2H). 6.80 (s, 1H), 7.16 (s, 1H), 7.26 (s, 1H), 7.30 (s, 1H), 7.47 (s, 1H), 8.64 (s, 1H) ppm.

References

[1] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00197
[2] Patent: US2014/228361, 2014, A1. Location in patent: Paragraph 0277-0278
[3] Patent: US2014/206664, 2014, A1. Location in patent: Paragraph 0225; 0229
[4] Patent: EP2796451, 2014, A1. Location in patent: Paragraph 0082

Gefitinib InterMediate B Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Gefitinib InterMediate B manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Gefitinib InterMediate B 912556-91-3
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-17

Career Henan Chemical Co

Product: Gefitinib InterMediate B 912556-91-3
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-10

912556-91-3, Gefitinib InterMediate BRelated Search:

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N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-Methoxyquinazolin-4-aMine

Gefitinib InterMediate B

6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-

Gefitinib InterMediate B ISO 9001：2015 REACH

N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-4-quinazolinamine

912556-91-3

C18H16Cl2FN3O2