1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
- Product Name
- 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
- CAS No.
- 41332-24-5
- Chemical Name
- 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
- Synonyms
- Z160;39-1B4;CS-2371;NP 118809;NP118809 (39-1B4;39-1B4; NP-118809;NP 118809;NP118809;NP118809, 10 mM in DMSO;1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3;1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
- CBNumber
- CB22544418
- Molecular Formula
- C32H32N2O
- Formula Weight
- 460.61
- MOL File
- 41332-24-5.mol
1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone Property
- Boiling point:
- 618.9±55.0 °C(Predicted)
- Density
- 1.142±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO : 50 mg/mL (108.55 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- 5.99±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D491935
- Product name
- 1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- CS-1361
- Product name
- NP118809
- Purity
- 98.62%
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3934AH
- Product name
- 1-(4-Benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one
- Packaging
- 100mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FD22501
- Product name
- 1-(Diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
- Packaging
- 100mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- FD22501
- Product name
- 1-(Diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
- Packaging
- 250mg
- Price
- $280
- Updated
- 2021/12/16
1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone Chemical Properties,Usage,Production
Uses
An analog of Cinnarizine (C465300), a calcium channel blocker as anti-inflammatory agent.
Synthesis
606-83-7
841-77-0
41332-24-5
Procedure for the synthesis of 1-(Diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine: to an anhydrous dichloromethane (40 mL) solution of 1-(Diphenylmethyl)piperazine (2.08 mmol), under nitrogen protection, was added 3,3 -diphenylpropionic acid (0.472 g, 2.08 mmol). Subsequently, EDC (0.797 g, 4.16 mmol) and a catalytic amount of DMAP were added to the reaction mixture, which was stirred overnight at room temperature under nitrogen atmosphere. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was dissolved in a solvent mixture of ethyl acetate and water (10:1, 150 mL). The organic phase was washed sequentially with water (30 mL, twice) and 10% NaOH solution (30 mL), dried with anhydrous magnesium sulfate and evaporated under reduced pressure to remove the solvent. The crude product obtained was purified by column chromatography with the eluent being a mixture of petroleum ether and ethyl acetate (3:1), and the target product 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine was finally obtained in 78% yield.
in vivo
NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model[1]. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model[2].
IC 50
N-type calcium channel: 0.11 μM (IC50); L-type calcium channel: 12.2 μM (IC50)
References
[1] Patent: US2004/259866, 2004, A1
[2] Patent: US6951862, 2005, B2
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 22, p. 6467 - 6472
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1378 - 1383
1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone manufacturers
- Product
- 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone 41332-24-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2020-01-08