(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate

Product Name: (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate
CAS No.: 250159-48-9
Chemical Name: (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate
Synonyms: Platinum hydrate;Miriplatin hydrate;Miriplatin monohydrate;(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate;SM-11355 (hydrate)|||Miripla|||Miriplatin|||SM 11355|||SM11355|||SM-11355|||Miriplatin hydrate
CBNumber: CB22565875
Molecular Formula: C34H68N2O5Pt
Formula Weight: 780.01
MOL File: 250159-48-9.mol

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(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate Property

storage temp.: Store at -20°C
solubility: 25℃: DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0019571
Product name: MIRIPLATIN HYDRATE
Purity: 95.00%
Packaging: 5MG
Price: $496.98
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 17572
Product name: Miriplatinhydrate
Purity: 98%
Packaging: 5mg
Price: $990
Updated: 2021/12/16

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(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate Chemical Properties,Usage,Production

Uses

Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents.

Biological Activity

Miriplatin hydrate (SM-11355 hydrate) is an effective chemotherapeutic agent and is a kind of alkylator.

in vitro

Miriplatin suspended in lipiodol (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis.

in vivo

Miriplatin (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells.

References

[1] Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23(3):344-8. DOI:10.1248/bpb.23.344
[2] Hanada M, et al. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis. Cancer Chemother Pharmacol. 2009 Aug;64(3):473-83. DOI:10.1007/s00280-008-0895-3

(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate Suppliers

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Musechem

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250159-48-9, (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrateRelated Search:

Cisplatin Carboplatin cis-Diamminediiodoplatinum Nedaplatin LOBAPLATIN DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Picoplatin Eptaplatin Satraplatin DIBROMO(1,5-CYCLOOCTADIENE)PLATINUM(II)

(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN']bis(tetradecanoato-kO)platinum monohydrate

Miriplatin hydrate

Miriplatin monohydrate

Platinum hydrate

SM-11355 (hydrate)|||Miripla|||Miriplatin|||SM 11355|||SM11355|||SM-11355|||Miriplatin hydrate

250159-48-9

C34H68N2O4PtH2O

Anticancer