Methyl 2,3-dichloropropionate
- Product Name
- Methyl 2,3-dichloropropionate
- CAS No.
- 3674-09-7
- Chemical Name
- Methyl 2,3-dichloropropionate
- Synonyms
- 2,3-dichloropropionate;METHYL-A,B-DICHLOROPROPIONATE;METHYL 2,3-DICHLOROPROPIONATE;Methyl 2,3-dichloropropanoate;Methyl2,3-Dichloropropionate>Methyl 2,3-dichloropropionate,98%;METHYL ALPHA,BETA-DICHLOROPROPIONATE;2,3-dichloro-propanoicacimethylester;2,3-Dichloropropionic Acid Methyl Este;2,3-DICHLOROPROPIONIC ACID METHYL ESTER
- CBNumber
- CB2257329
- Molecular Formula
- C4H6Cl2O2
- Formula Weight
- 157
- MOL File
- 3674-09-7.mol
Methyl 2,3-dichloropropionate Property
- Boiling point:
- 52-55 °C/2 mmHg (lit.)
- Density
- 1.325 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.453(lit.)
- Flash point:
- 145 °F
- storage temp.
- Store below +30°C.
- solubility
- Soluble in ether, acetone, ethanol.
- color
- Colorless to Almost colorless
- BRN
- 1701891
- InChI
- InChI=1S/C4H6Cl2O2/c1-8-4(7)3(6)2-5/h3H,2H2,1H3
- InChIKey
- OFHMODDLBXETIK-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C(Cl)CCl
- CAS DataBase Reference
- 3674-09-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Propanoic acid, 2,3-dichloro-, methyl ester(3674-09-7)
- EPA Substance Registry System
- Propanoic acid, 2,3-dichloro-, methyl ester (3674-09-7)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-10
- Safety Statements
- 23-24/25-37/39-26-16
- RIDADR
- 1993
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29159000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8.18319
- Product name
- Methyl 2,3-dichloropropionate
- Purity
- for synthesis
- Packaging
- 10ml
- Price
- $44.2
- Updated
- 2024/03/01
- Product number
- D0408
- Product name
- Methyl 2,3-Dichloropropionate
- Purity
- >95.0%(GC)
- Packaging
- 10g
- Price
- $26
- Updated
- 2024/03/01
- Product number
- B21993
- Product name
- Methyl 2,3-dichloropropionate, 98%
- Packaging
- 25g
- Price
- $46.65
- Updated
- 2024/03/01
- Product number
- B21993
- Product name
- Methyl 2,3-dichloropropionate, 98%
- Packaging
- 100g
- Price
- $102.65
- Updated
- 2024/03/01
- Product number
- B21993
- Product name
- Methyl 2,3-dichloropropionate, 98%
- Packaging
- 500g
- Price
- $396.65
- Updated
- 2024/03/01
Methyl 2,3-dichloropropionate Chemical Properties,Usage,Production
Chemical Properties
clear colorless to slightly yellow liquid
Uses
Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate.
Application
Methyl 2,3-Dichloropropanoate is a useful reagent in preparation of oxidative fragmentation and coupling of catharanthine analogs to vindoline.
Synthesis
Preparation of Methyl 2,3-dichloropropanoate:
Methyl acrylate (2366 g, 27.5 mol) and dimethylformamide (DMF) (40 g, 0.55 mol) was placed in a 3-liter three necked flask fitted with a stirrer, thermometer, inlet tube and gas trap. Chlorine (950 g, 0.48 mol) was passed into the methyl acrylate rapidly over a period of ten hours while the temperature was kept below 40°C. Reaction progress was monitored by gas chromatography (GC). When it seemed that 50 percent of chlorine was consumed, the reaction was stopped. The reaction mass was taken for distillation to separate methylacrylate and Methyl 2,3-dichloropropanoate. The contents were subjected to vacuum distillation. Methyl 2,3-dichloropropanoate was collected distilling at 70°C with 15mm.Yield (%):77.2, Purity (%) = 98.
Methyl 2,3-dichloropropionate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2,3-dichloropropionate Suppliers
- Tel
- --
- Fax
- --
- kevinbanks@molekula.com
- Country
- United Kingdom
- ProdList
- 6140
- Advantage
- 66
- Tel
- --
- Fax
- --
- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
- Tel
- --
- Fax
- --
- ariac@web.am
- Country
- United Kingdom
- ProdList
- 2466
- Advantage
- 46
- Tel
- --
- Fax
- --
- sheila@mda-chem.co.uk
- Country
- United Kingdom
- ProdList
- 1961
- Advantage
- 30
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
View Lastest Price from Methyl 2,3-dichloropropionate manufacturers
- Product
- Methyl 2,3-dichloropropionate 3674-09-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-28
- Product
- Methyl 2,3-dichloropropionate 3674-09-7
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-19
- Product
- Methyl 2,3-dichloropropanoate 3674-09-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30