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UNC0638

Product Name
UNC0638
CAS No.
1255580-76-7
Chemical Name
UNC0638
Synonyms
CS-565;UNC0638;UNC0638/UNC-0638;UNC0638, 10 mM in DMSO;HMTase Inhibitor IV, UNC0638;UNC0638, G9 and GLP histone methyltransferase inhibitor;2-Cyclohexyl-N-(1-isopropyl-4-piperidinyl)-6-Methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-cyclohexyl-6-methoxy-n-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine;2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
CBNumber
CB22592813
Molecular Formula
C30H47N5O2
Formula Weight
509.73
MOL File
1255580-76-7.mol
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UNC0638 Property

Melting point:
93-94℃
Boiling point:
610.2±55.0 °C(Predicted)
Density 
1.124±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
≥25.5 mg/mL in DMSO; insoluble in H2O; ≥48.2 mg/mL in EtOH
form 
solid
pka
10.07±0.20(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10734
Product name
UNC0638
Purity
≥98%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
10734
Product name
UNC0638
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
10734
Product name
UNC0638
Purity
≥98%
Packaging
10mg
Price
$210
Updated
2024/03/01
Cayman Chemical
Product number
10734
Product name
UNC0638
Purity
≥98%
Packaging
50mg
Price
$936
Updated
2024/03/01
Tocris
Product number
4343
Product name
UNC0638
Purity
≥98%(HPLC)
Packaging
10
Price
$255
Updated
2021/12/16
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UNC0638 Chemical Properties,Usage,Production

Uses

2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine, is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP.

Definition

ChEBI: 2-cyclohexyl-6-methoxy-N-(1-propan-2-yl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine is a member of quinazolines.

Biological Activity

unc0638 is a potent and selective inhibitor of g9a and glp with ic50 values of < 15 nm and 19 ± 1 nm, respectively [1].glp forms a heterodimer with g9a. both g9a and glp can mono- and dimethylate histone h3 lys9 (h3k9), and dimethylate lys373 of p53 and hence inactivate the transcriptional activity of p53 [1].unc0638 showed balanced physicochemical properties and potency aiding cell penetration in vitro, had high potency in cellular assays. it was much less toxic than bix01294 to cells. in mda-mb-231 cells, in a concentration-dependent manner, exposure to unc0638 for 48 h reduced h3k9me2 levels with an ic50 value of 81 ± 9 nm (n= 3), which showed considerably higher potency than bix01294 (ic50= 500 ± 43 nm (n= 3)). in reducing h3k9me2 levels, unc0638 was of greater maximum effect than bix01294. this effect is close, but not equal, to the effect on the double knockdown of g9a and glp via shrna [1].in 6-week-old male athymic nude mice subcutaneously inoculated with bon cells, unc0638 decreased h3k9me2 level [2]. in organotypic cochlear cultures, rapid increase of h3k9me2 upon the damage of hair cells was observed. both ex vivo and in vivo, unc0638 effectively prevented aminoglycosides-induced hair cell damage [3].

target

G9a

storage

Store at +4°C

References

[1]. vedadi m., barsyte-lovejoy d., liu f., et al. a chemical probe selectively inhibits g9a and glp methyltransferase activity in cells. nature chemical biology, 2011, 7:566-574.
[2]. kim j.t., li j., jang e.r., et al. deregulation of wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors. clin. carcinogenesis, 2013, 00(00):1-9.
[3]. yu h., lin q., wang y., et al. inhibition of h3k9 methyltransferases g9a/glp prevents ototoxicity and ongoing hair cell death. cell death and disease, 2013, 4:e506.

UNC0638 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC0638 Suppliers

ApexBio Technology LLC
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+1-832-696-8203
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+1-832-641-3177
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info@apexbt.com
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United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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United States
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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Cckinase, Inc.
Tel
+1 (732)236-3202
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sales@cckinase.com
Country
United States
ProdList
2738
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58
BOC Sciences
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+1-631-485-4226
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1-631-614-7828
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inquiry@bocsci.com
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United States
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Aladdin Scientific
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Email
tp@aladdinsci.com
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United States
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57505
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TargetMol Chemicals Inc.
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support@targetmol.com
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United States
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ApexBio Technology
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Abcam Limited
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us.orders@abcam.com
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United States
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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Creative Enzymes
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NE Scientific
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View Lastest Price from UNC0638 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
UNC0638 1255580-76-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
UNC0638 1255580-76-7
Price
US $0.10/g
Min. Order
1g
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-10

1255580-76-7, UNC0638Related Search:


  • UNC0638
  • CS-565
  • UNC0638/UNC-0638
  • 2-Cyclohexyl-N-(1-isopropyl-4-piperidinyl)-6-Methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine
  • 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine
  • UNC0638 2-Cyclohexyl-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine
  • 2-cyclohexyl-6-methoxy-n-(1-propan-2-ylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine
  • 4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
  • UNC0638, G9 and GLP histone methyltransferase inhibitor
  • UNC0638, 10 mM in DMSO
  • HMTase Inhibitor IV, UNC0638
  • 1255580-76-7
  • C30H47N5O2
  • Epigenetics