ChemicalBook > CAS DataBase List > PD 0332991 HCl

PD 0332991 HCl

Product Name
PD 0332991 HCl
CAS No.
827022-32-2
Chemical Name
PD 0332991 HCl
Synonyms
CS-365;PD 0332991 HCl;Palbociclib HCl;Palbociclib-025;Palbociclib-019-HCl;PD 0332991;PD-0332991;PD 0332991 hydrochloride;PD-0332991 (Palbociclib);PD 0332991 HCl USP/EP/BP;Palbociclib (hydrochloride)
CBNumber
CB22593007
Molecular Formula
C24H30ClN7O2
Formula Weight
484
MOL File
827022-32-2.mol
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PD 0332991 HCl Property

storage temp. 
= -70C
solubility 
≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
form 
Yellow liquid
color 
Light yellow to yellow
Water Solubility 
water: 10mg/mL
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Safety

HS Code 
29399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.30487
Product name
StemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem
Packaging
5mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
16273
Product name
PD 0332991 (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$353
Updated
2024/03/01
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PD 0332991 HCl Chemical Properties,Usage,Production

Description

PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.

General Description

A cell-permeable, orally available and brain permeant, non-toxic pyridopyrimidinone compound that acts as a potent, selective, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC50 = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk6/D2, respectively). Hence, it reduces retinoblastoma protein phosphorylation at Ser780/Ser795 (IC50 = 66 nM in MDA-435 cells) and arrests cell cycle at G1 phase. Acts as a cytostatic agent, but does induce apoptotic cell death when used alone. However, it potentiates the cytotoxicity of dexamethasone (>Cat. No. 265005), bortezomib (>Cat. No. 504314), and tamoxifen (Cat. No. 579000) in estrogen receptor (ER)-positive cell lines. Exhibits only a trivial inhibitory activity towards Cdk2/E2, Cdk2/A, Cdk1/B and Cdk5/p25 in a 36-kinase panel (IC50 >10 μM). Improves endoderm differentiation of late G1-human embryonic stem cells expressing Smad2 or Smad3 (~ 750 nM) and further enhances endoderm differentiation into hepatic and pancreatic progenitor cells. Shown to regress the growth of human breast tumor xenografts in murine models (~150 mg/kg, p.o., daily).

Biochem/physiol Actions

Cell permeable: yes

target

CDK4/cyclin D1

References

[1] ivan diaz-padilla, lillian l. siu and ignacio duran. cyclin-dependent kinase inhibitors as potential targeted anticancer agents. invest new drugs. 2009, 27: 586–594.
[2] richard s finn, judy dering, dylan conklin, ondrej kalous, david j cohen, amrita j desai, charles ginther, mohammad atefi, isan chen, camilla fowst, gerret los and dennis j slamon. pd 0332991, a selective cyclin d kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. breast cancer research. 2009, 11: r77.

PD 0332991 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 0332991 HCl Suppliers

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View Lastest Price from PD 0332991 HCl manufacturers

Henan Fengda Chemical Co., Ltd
Product
PD 0332991 HCl 827022-32-2
Price
US $31.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-25
Dideu Industries Group Limited
Product
PD 0332991 HCl 827022-32-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-17
Career Henan Chemical Co
Product
PD 0332991 HCl 827022-32-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-23

827022-32-2, PD 0332991 HClRelated Search:

PD0332991 Isethionate 6-acetyl-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol Flupirtine maleate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- Palbociclib 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one MK-2206 2HCl Ribociclib Trametinib (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

  • PD 0332991 HCl
  • PALBOCICLIB HCL; PD0332991 HCL
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride Palbociclib (PD-0332991) HCl
  • Palbociclib hydrochloride, >=98%
  • PD-0332991 (Palbociclib)
  • PD 0332991 hydrochloride
  • Palbociclib HCl
  • Palbociclib (hydrochloride)
  • Palbociclib (PD-0332991) HCl
  • 6-acetyl-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one hydrochloride
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
  • PD 0332991 HCl (Palbociclib)
  • Palbociclib-025
  • PD 0332991 (Palbociclib) HCl
  • CS-365
  • Palbociclib-019-HCl
  • PD 0332991;PD-0332991
  • Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-,monohydrochloride
  • Palbociclib (PD-0332991) hydrochloride
  • 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one hydrochloride
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)pyrido[2,3-d]pyrimidin-
  • Palbociclib hydrochloride, 99%, a highly selective CDK4/6 inhibitor
  • PALBOCICLIB;PD-0332991 HYDROCHLORIDE;PD0332991 HYDROCHLORIDE;PD 0332991 HYDROCHLORIDE
  • Palbociclib, brand name: Ibrance
  • PD 0332991; PD-0332991; PD0332991; PD0332991; PD332991; PD-332991; PD 332991; PALBOCICLIB, BRAND NAME: IBRANCE
  • PD 0332991 HCl USP/EP/BP
  • Pyrido[2,3-d]pyrimidin-7(8H)-one,6-acetyl-8-cyclopentyl-5-me...
  • Palbociclib (monohydrochloride)
  • TIANFU-CHEM CAS:827022-32-2 PD 0332991 HCl
  • 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride1
  • PALBOCICLIB (PD-0332991) (HCL SALT)
  • Palbociclib Impurity 22 HCl
  • Palbociclib Impurity 20 HCl
  • PD 0332991 hydrochloride(1:1)
  • 827022-32-2
  • C24H29N7O2HCl
  • C24H30ClN7O2
  • C24H29N7O2ClH
  • Inhibitors