ChemicalBook > CAS DataBase List > D-DESTHIOBIOTIN

D-DESTHIOBIOTIN

Product Name
D-DESTHIOBIOTIN
CAS No.
533-48-2
Chemical Name
D-DESTHIOBIOTIN
Synonyms
DESTHIOBIOTIN;Dethiobiotin;6-((4R,5S)-5-Methyl-2-oxoiMidazolidin-4-yl)hexanoic acid;ethiobiotin;CAS_533-48-2;D-Dethiobiotin;D-DESTHIOBIOTIN;DL-DESTHIOBIOTIN;Desulfurized biotin;D-desulfurized biotin
CBNumber
CB2259792
Molecular Formula
C10H18N2O3
Formula Weight
214.26
MOL File
533-48-2.mol
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D-DESTHIOBIOTIN Property

Melting point:
156-158°
alpha 
D21 +10.7° (c = 2)
Boiling point:
354.4°C (rough estimate)
Density 
1.1404 (rough estimate)
refractive index 
1.4550 (estimate)
storage temp. 
2-8°C
solubility 
Aqueous Base (Slightly), DMSO (Slightly)
form 
Solid
pka
4.77±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)/t7-,8+/m0/s1
InChIKey
AUTOLBMXDDTRRT-UHFFFAOYSA-N
SMILES
C1(=O)N[C@@H](C)[C@@H](CCCCCC(O)=O)N1
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1411
Product name
d-Desthiobiotin
Purity
≥98% (TLC)
Packaging
500mg
Price
$200
Updated
2025/07/31
Sigma-Aldrich
Product number
D1411
Product name
d-Desthiobiotin
Purity
≥98% (TLC)
Packaging
1g
Price
$341
Updated
2025/07/31
Sigma-Aldrich
Product number
71610-M
Product name
D-Desthiobiotin
Packaging
1g
Price
$477
Updated
2025/07/31
Cayman Chemical
Product number
30418
Product name
D-Desthiobiotin
Packaging
100mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
30418
Product name
D-Desthiobiotin
Packaging
250mg
Price
$118
Updated
2024/03/01
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D-DESTHIOBIOTIN Chemical Properties,Usage,Production

Uses

D-Desthiobiotin is an analogue of Biotin (B389040) that binds less tightly to biotin-binding proteins such as Avidin and is easily displaced by Biotin.

Definition

ChEBI: (4R,5S)-dethiobiotin is the (4R,5S)-isomer of dethiobiotin. It is a conjugate acid of a (4R,5S)-dethiobiotin(1-). It is an enantiomer of a (4S,5R)-dethiobiotin.

Biological Activity

Desthiobiotin is a non-sulfur containing biotin derivative th at binds less strongly to biotin-binding proteins and is easily dislocated by biotin.

IC 50

Microbial Metabolite; Human Endogenous Metabolite

Purification Methods

Dissolve desthiobiotin in 0.5% Na2CO3, filter, acidify with HCl to Congo Red, concentrate to a small volume (2-3 mL) to give fine needles, filter it off and recrystallise it twice from H2O, m 157-158o. It also crystallises from 95% EtOH. The methyl ester crystallises from MeOH and sublimes at 100o/high vacuum, m 69-70o, [] D +2.6o (c 2, CHCl3). [Melville et al. Science 98 497 1943, J Am Chem Soc 66 1422 1944, Beilstein 25 III/IV 1543.]

D-DESTHIOBIOTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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D-DESTHIOBIOTIN Suppliers

China 134 India 2 Switzerland 1 United Kingdom 2 United States 12 Global 151
Shanghai TenSus Biotechnology Co., Ltd.
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View Lastest Price from D-DESTHIOBIOTIN manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Dethiobiotin 533-48-2
Price
US $0.00/g
Min. Order
5g
Purity
>95.00%
Supply Ability
5g
Release date
2024-03-30
Dideu Industries Group Limited
Product
D-DESTHIOBIOTIN 533-48-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-30

533-48-2, D-DESTHIOBIOTINRelated Search:

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  • 5-METHYL-2-OXO-4-IMIDAZOLINE-CAPROIC ACID
  • DL-DESTHIOBIOTIN
  • CAS_533-48-2
  • D-DESTHIOBIOTIN
  • DESTHIOBIOTIN
  • (4R-cis)-5-methyl-2-oxoimidazolidine-4-hexanoic acid
  • 6-(5-methyl-2-oxo-imidazolidin-4-yl)hexanoic acid
  • Dethiobiotin
  • 5-Methyl-2-oxo-4-imidazolidinehexanoic acid
  • (4R)-2-Oxo-5α-methylimidazolidine-4α-hexanoic acid
  • [4R,5S,(+)]-5-Methyl-2-oxo-4-imidazolidinehexanoic acid
  • 6-((4R,5S)-5-Methyl-2-oxoiMidazolidin-4-yl)hexanoic acid
  • 4-Imidazolidinehexanoic acid, 5-methyl-2-oxo-, (4R,5S)-
  • d-Desthiobiotin >=98% (TLC)
  • Desulfurized biotin
  • D-DESTHIOBIOTIN USP/EP/BP
  • D-desulfurized biotin
  • ethiobiotin
  • D-Dethiobiotin
  • D-Desthiobiotin, 10 mM in DMSO
  • <i>d</i>-Desthiobiotin
  • 533-48-2