GNE-493

Product Name: GNE-493
CAS No.: 1033735-94-2
Chemical Name: GNE-493
Synonyms: CS-1783;GNE-493;GNE 493;GNE493;GNE-493, 10 mM in DMSO;2-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol; 2-[2-(2-aminopyrimidin-5-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]propan-2-ol;Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-;2-(2-Amino-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol;GNE493,Mammalian target of Rapamycin,PI3K,Inhibitor,inhibit,GNE-493,Phosphoinositide 3-kinase,mTOR,GNE 493;2-(2-Amino-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol GNE-493
CBNumber: CB22621137
Molecular Formula: C17H20N6O2S
Formula Weight: 372.44
MOL File: 1033735-94-2.mol

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GNE-493 Property

Density: 1.408±0.06 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: DMF:20.0(Max Conc. mg/mL);53.7(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.34(Max Conc. mM)
DMSO:45.0(Max Conc. mg/mL);120.82(Max Conc. mM)
Ethanol:1.1(Max Conc. mg/mL);2.95(Max Conc. mM)
pka: 13.17±0.29(Predicted)
form: Powder
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29224
Product name: GNE-493
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 29224
Product name: GNE-493
Packaging: 25mg
Price: $1201
Updated: 2024/03/01

Cayman Chemical

Product number: 29224
Product name: GNE-493
Packaging: 5mg
Price: $362
Updated: 2024/03/01

Cayman Chemical

Product number: 29224
Product name: GNE-493
Packaging: 10mg
Price: $601
Updated: 2024/03/01

ChemScene

Product number: CS-3358
Product name: GNE-493
Purity: 95.12%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

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GNE-493 Chemical Properties,Usage,Production

Uses

GNE-493 is a potent, selective, and orally available dual pan-PI3-kinase/mTOR inhibitor with IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.

in vivo

To confirm and compare in vivo efficacy, GNE-493 is examined in the human MCF7.1 breast cancer xenograft model that harbors a PI3Kα activating mutation. Mice bearing xenografts are dosed orally once daily with 10 mg/kg of GNE-493 for 21 continuous days. Similar to observations made in the PC3 prostate cancer xenograft model, 10 mg/kg of GNE-493 results in 73% tumor growth inhibition at day 21 when compared to vehicle control animals. When achieving comparable levels of drug exposure, GNE-493 shows a similar suppression of the PI3K pathway and consequently, a similar efficacy profile against MCF7.1 breast tumors^[1].

IC 50

PI3Kα: 3.4 nM (IC₅₀); PI3Kβ: 12 nM (IC₅₀); PI3Kδ: 16 nM (IC₅₀); PI3Kγ: 16 nM (IC₅₀); mTOR: 30 nM (IC₅₀)

References

[1] Sutherlin DP, et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53(3):1086-97. DOI:10.1021/jm901284w

GNE-493 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-493 Suppliers

China 76 United Kingdom 1 United States 10 Global 87

Shanghai Boyle Chemical Co., Ltd.

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Fax: 86-21-57758967
Email: sales@boylechem.com
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
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SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
ProdList: 266
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
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LETOPHARM LIMITED

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Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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SPIRO PHARMA

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BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
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View Lastest Price from GNE-493 manufacturers

Career Henan Chemical Co

Product: 2-[2-(2-aminopyrimidin-5-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]propan-2-ol 1033735-94-2
Price: US $1.00/KG
Min. Order: 1g
Purity: Min98% HPLC
Supply Ability: g/kg /ton
Release date: 2019-12-20

1033735-94-2, GNE-493Related Search:

GNE-3511 GNE-490 GNE-9605 GNE-6640 GNF 5837 GNE 477 GNE-955 GNE140 gne-131 GNE 617 GNE 7915

GNE-493

2-(2-Amino-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol

CS-1783

GNE 493;GNE493

2-[2-(2-aminopyrimidin-5-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]propan-2-ol

2-(2-Amino-5-pyrimidinyl)-alpha,alpha-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol GNE-493

2-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol

Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-

GNE493,Mammalian target of Rapamycin,PI3K,Inhibitor,inhibit,GNE-493,Phosphoinositide 3-kinase,mTOR,GNE 493

GNE-493, 10 mM in DMSO

1033735-94-2

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