GNE 7915

Product Name: GNE 7915
CAS No.: 1351761-44-8
Chemical Name: GNE 7915
Synonyms: CS-1279;GNE 7915;GNE-7915, >=98%;GNE7915; GNE 7915;GNE 7915 USP/EP/BP;LRRK2,inhibit,GNE-7915,Inhibitor,Leucine-rich repeat kinase 2,GNE 7915;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
CBNumber: CB02667096
Molecular Formula: C19H21F4N5O3
Formula Weight: 443.4
MOL File: 1351761-44-8.mol

More

Less

GNE 7915 Property

Melting point:: 143 - 144°C
Boiling point:: 629.9±65.0 °C(Predicted)
Density: 1.404±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: solid
pka: 2.80±0.10(Predicted)
CAS DataBase Reference: 1351761-44-8

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 16252
Product name: GNE-7915
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16252
Product name: GNE-7915
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 16252
Product name: GNE-7915
Purity: ≥98%
Packaging: 50mg
Price: $547
Updated: 2024/03/01

Usbiological

Product number: 451389
Product name: GNE 7915
Packaging: 10mg
Price: $410
Updated: 2021/12/16

TRC

Product number: G766100
Product name: GNE7915
Packaging: 10mg
Price: $120
Updated: 2021/12/16

More

Less

GNE 7915 Chemical Properties,Usage,Production

Uses

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]

Uses

GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).

GNE 7915 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GNE 7915 Suppliers

China 83 India 2 United States 17 Global 102

Suzhou Chenrui Biotechnology Co. LTD

Tel: 17625585511
Fax: qq：1580084073
Email: 1580084073@qq.com
Country: China
ProdList: 462
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376090521
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 996
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Hangzhou J&H Chemical Co., Ltd.

Tel: +86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 10015
Advantage: 53

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

More

Less

View Lastest Price from GNE 7915 manufacturers

Career Henan Chemical Co

Product: GNE 7915 1351761-44-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

1351761-44-8, GNE 7915Related Search:

Temsirolimus S3I-201 Lenvatinib GNE-3511 GNE-490 GNE-9605 GNE-6640 GNF 5837 GNE 477 GNE-955 GNE140 GNE-493 gne-131 GNE 617 MK-1775 Axitinib PF 573228

GNE 7915

[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone

GNE-7915, >=98%

(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol

(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

CS-1279

GNE7915; GNE 7915

Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-

GNE 7915 USP/EP/BP

LRRK2,inhibit,GNE-7915,Inhibitor,Leucine-rich repeat kinase 2,GNE 7915

1351761-44-8

C26H29F4N5O6S

C19H21F4N5O3

Inhibitors

api