GNE-955

Product Name: GNE-955
CAS No.: 1527523-39-2
Chemical Name: GNE-955
Synonyms: GNE-955;GNE955,GNE 955;GNE-955( 5-Azaindazole);(3S)-1-[3-Methoxy-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]pyridin-2-yl]piperidin-3-amine;3-Piperidinamine, 1-[3-methoxy-6-[6-(6-methyl-2-pyrazinyl)-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-pyridinyl]-, (3S)-
CBNumber: CB53362074
Molecular Formula: C22H24N8O
Formula Weight: 416.48
MOL File: 1527523-39-2.mol

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GNE-955 Property

Boiling point:: 615.2±55.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 9.90±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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GNE-955 Chemical Properties,Usage,Production

Description

GNE-955 is a Potent Pan-Pim Inhibitor. GNE-955 is potent and has excellent bioavailability in rat.

Uses

GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

IC 50

PIM1: 0.018 nM (Ki); PIM2: 0.11 nM (Ki); PIM3: 0.08 nM (Ki)

References

[1] Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60(10):4458-4473. DOI:10.1021/acs.jmedchem.7b00418

GNE-955 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-955 Suppliers

China 12 United States 2 Global 14

Chembest Research Laboratories Limited

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1527523-39-2, GNE-955Related Search:

GNE-3511 GNE-490 GNE-9605 GNE-6640 GNF 5837 GNE 477 GNE140 GNE-493 gne-131 GNE 617 GNE 7915

GNE-955

GNE-955( 5-Azaindazole)

GNE955,GNE 955

3-Piperidinamine, 1-[3-methoxy-6-[6-(6-methyl-2-pyrazinyl)-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-pyridinyl]-, (3S)-

(3S)-1-[3-Methoxy-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]pyridin-2-yl]piperidin-3-amine

1527523-39-2