GNE140

Product Name: GNE140
CAS No.: 2003234-63-5
Chemical Name: GNE140
Synonyms: GNE140;CS-2624;(R)-GNE-140;CAS:2003234-63-5;(R)-GNE-140 ，S6675;(R)-GNE-140 (GNE-140;GNE-140;GNE 140;GNE140;(R)-GNE-140, 10 mM in DMSO;Inhibitor,LDH,(R) GNE 140,inhibit,Lactate Dehydrogenase,(R)GNE140;(R)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one
CBNumber: CB43353026
Molecular Formula: C25H23ClN2O3S2
Formula Weight: 499.04
MOL File: 2003234-63-5.mol

More

Less

GNE140 Property

Boiling point:: 695.4±55.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO:14.4(Max Conc. mg/mL);28.9(Max Conc. mM)
pka: 4.50±1.00(Predicted)
form: Solid
color: Light yellow to yellow
InChIKey: SUFXXEIVBZJOAP-RUZDIDTESA-N
SMILES: C1(=O)N[C@](C2=CC=C(N3CCOCC3)C=C2)(C2C=CSC=2)CC(O)=C1SC1=CC=CC=C1Cl

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2580
Product name: GNE-140
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $155.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2580
Product name: GNE-140
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $634
Updated: 2025/07/31

ChemScene

Product number: CS-7646
Product name: (R)-GNE-140
Purity: 99.20%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-7646
Product name: (R)-GNE-140
Purity: 99.20%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 3081EG
Product name: (2R)-5-(2-Chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-one
Packaging: 10mg
Price: $286
Updated: 2021/12/16

More

Less

GNE140 Chemical Properties,Usage,Production

Description

GNE140 ((R)-GNE-140) is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

Uses

(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

Biochem/physiol Actions

GNE-140 is an active site-targeting, potent and selective lactate dehydrogenase (LDH) inhibitor (LDH-A/B/C IC50 = 3/5/5 nM; LDH-A IC50 = 22 nM with mixed GNE-140 diastereomers; malate dehydrogenases MDH1/2 IC50 >10 μM; 301 kinases IC50 >1 μM) that reduces cellular lactate (IC50 = 670 nM; MIA PaCa-2) and upregulates pyruvate levels. GNE-140 affects glycolysis-dependent cancer proliferation (IC50 = 430 nM; MIA PaCa-2 & KP-2) & survival, but not oxidative phosphorylation (OXPHOS)-dependent growth. Due to rapid clearance, GNE-140 is ineffective against MIA PaCa-2 tumor growth with only transient lactate-reducing efficacy in tumor tissue in mice in vivo (100-400 mg/kg b.i.d. p.o.).

in vivo

(R)-GNE-140 (5 mg/kg) has high bioavailability in mice. At higher oral doses, ranging from 50 to 200 mg/kg, (R)-GNE-140 displays greater exposure.

References

[1] Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901. DOI:10.1021/acsmedchemlett.6b00190

GNE140 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GNE140 Suppliers

China 84 India 1 United States 5 USA 1 Global 91

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-024-88590548 18341751992
Email: 757984502@qq.com
Country: China
ProdList: 942
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Shanghai Gugang New Materials Technology Co. Ltd.

Tel: 021-51317962
Fax: 021-51317962
Email: 296935822@qq.com
Country: China
ProdList: 986
Advantage: 58

2003234-63-5, GNE140Related Search:

GNE-3511 GNE-490 GNE-9605 GNE-6640 GNF 5837 GNE 477 GNE-955 GNE-493 gne-131 GNE 617 GNE 7915

GNE-140;GNE 140;GNE140

(R)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one

(R)-GNE-140 (GNE-140

GNE140

(R)-GNE-140

CS-2624

2(1H)-Pyridinone, 3-[(2-chlorophenyl)thio]-5,6-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-, (6R)-

Inhibitor,LDH,(R) GNE 140,inhibit,Lactate Dehydrogenase,(R)GNE140

(R)-GNE-140, 10 mM in DMSO

CAS:2003234-63-5

(R)-GNE-140 ，S6675

(6R)-3-[(2-chlorophenyl)thio]-5,6-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-2(1H)-pyridinone

(R)-3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholin-4-ylphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one

2003234-63-5