GNE-6640

Product Name: GNE-6640
CAS No.: 2009273-67-8
Chemical Name: GNE-6640
Synonyms: CS-2824;GNE-6641;GNE-6640, 10 mM in DMSO;GNE-6640;GNE 6640;GNE6640;2009273-67-8;4-(2-Amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol;Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]-;Deubiquitinase,GNE6640,GNE-6640,DUBs,inhibit,Inhibitor,GNE 6640
CBNumber: CB64693453
Molecular Formula: C20H18N4O
Formula Weight: 330.38
MOL File: 2009273-67-8.mol

More

Less

GNE-6640 Property

Boiling point:: 595.5±50.0 °C(Predicted)
Density: 1.308±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:1.0(Max Conc. mg/mL);3.03(Max Conc. mM)
DMSO:3.0(Max Conc. mg/mL);9.08(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM)
form: A solid
pka: 8.23±0.15(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0069685
Product name: GNE-6640
Purity: 99.96%
Packaging: 5mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0069685
Product name: GNE-6640
Purity: 99.96%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0069685
Product name: GNE-6640
Purity: 99.96%
Packaging: 25mg
Price: $740
Updated: 2021/12/16

ChemScene

Product number: CS-0069685
Product name: GNE-6640
Purity: 99.96%
Packaging: 50mg
Price: $1200
Updated: 2021/12/16

ChemScene

Product number: CS-0069685
Product name: GNE-6640
Purity: 99.96%
Packaging: 100mg
Price: $1950
Updated: 2021/12/16

More

Less

GNE-6640 Chemical Properties,Usage,Production

Uses

GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively[1][2].

References

[1] Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538. DOI:10.1038/nature24006
[2] Tanguturi P, et al. The role of deubiquitinating enzymes in cancer drug resistance. Cancer Chemother Pharmacol. 2020 Apr;85(4):627-639. DOI:10.1007/s00280-020-04046-8

GNE-6640 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GNE-6640 Suppliers

China 45 India 1 United States 6 Global 52

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

2009273-67-8, GNE-6640Related Search:

GNE-3511 GNE-490 GNE-9605 GNF 5837 GNE 477 GNE-955 GNE140 GNE-493 gne-131 GNE 617 GNE 7915

CS-2824

GNE-6640;GNE 6640;GNE6640;2009273-67-8

Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]-

GNE-6641

Deubiquitinase,GNE6640,GNE-6640,DUBs,inhibit,Inhibitor,GNE 6640

4-(2-Amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol

GNE-6640, 10 mM in DMSO

2009273-67-8