GNE 7915
- Product Name
- GNE 7915
- CAS No.
- 1351761-44-8
- Chemical Name
- GNE 7915
- Synonyms
- CS-1279;GNE 7915;GNE-7915, >=98%;GNE7915; GNE 7915;GNE 7915 USP/EP/BP;LRRK2,inhibit,GNE-7915,Inhibitor,Leucine-rich repeat kinase 2,GNE 7915;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
- CBNumber
- CB02667096
- Molecular Formula
- C19H21F4N5O3
- Formula Weight
- 443.4
- MOL File
- 1351761-44-8.mol
GNE 7915 Property
- Melting point:
- 143 - 144°C
- Boiling point:
- 629.9±65.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- solid
- pka
- 2.80±0.10(Predicted)
- CAS DataBase Reference
- 1351761-44-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16252
- Product name
- GNE-7915
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 16252
- Product name
- GNE-7915
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 16252
- Product name
- GNE-7915
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $547
- Updated
- 2024/03/01
- Product number
- 451389
- Product name
- GNE 7915
- Packaging
- 10mg
- Price
- $410
- Updated
- 2021/12/16
- Product number
- G766100
- Product name
- GNE7915
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
GNE 7915 Chemical Properties,Usage,Production
Uses
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]
Uses
GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).
GNE 7915 Preparation Products And Raw materials
Raw materials
Preparation Products
GNE 7915 Suppliers
View Lastest Price from GNE 7915 manufacturers
- Product
- GNE 7915 1351761-44-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23