GNE 7915

ChemicalBook > CAS DataBase List > GNE 7915

Product Name: GNE 7915
CAS No.: 1351761-44-8
Chemical Name: GNE 7915
Synonyms: CS-1279;GNE 7915;GNE-7915, >=98%;GNE7915; GNE 7915;GNE 7915 USP/EP/BP;LRRK2,inhibit,GNE-7915,Inhibitor,Leucine-rich repeat kinase 2,GNE 7915;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
CBNumber: CB02667096
Molecular Formula: C19H21F4N5O3
Formula Weight: 443.4
MOL File: 1351761-44-8.mol

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GNE 7915 Property

Melting point:: 143 - 144°C
Boiling point:: 629.9±65.0 °C(Predicted)
Density: 1.404±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: solid
pka: 2.80±0.10(Predicted)
CAS DataBase Reference: 1351761-44-8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16252
Product name: GNE-7915
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16252
Product name: GNE-7915
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 16252
Product name: GNE-7915
Purity: ≥98%
Packaging: 50mg
Price: $547
Updated: 2024/03/01

Usbiological

Product number: 451389
Product name: GNE 7915
Packaging: 10mg
Price: $410
Updated: 2021/12/16

TRC

Product number: G766100
Product name: GNE7915
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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GNE 7915 Chemical Properties,Usage,Production

Uses

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]

Uses

GNE-7915 is a Blood-Brain Barrier (BBB) penetrable small molecule inhibitor of Leucine-Rich Repeat Kinase 2 (LRRK2).

GNE 7915 Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE 7915 Suppliers

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View Lastest Price from GNE 7915 manufacturers

Career Henan Chemical Co

Product: GNE 7915 1351761-44-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

1351761-44-8, GNE 7915Related Search:

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GNE 7915

[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone

GNE-7915, >=98%

(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol

(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

CS-1279

GNE7915; GNE 7915

Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-

GNE 7915 USP/EP/BP

LRRK2,inhibit,GNE-7915,Inhibitor,Leucine-rich repeat kinase 2,GNE 7915

1351761-44-8

C26H29F4N5O6S

C19H21F4N5O3

Inhibitors

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