ChemicalBook > CAS DataBase List > VX-661

VX-661

Product Name
VX-661
CAS No.
1152311-62-0
Chemical Name
VX-661
Synonyms
tezacaftor(VX661);(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxaMide;VX-661;CS-956;VX-661/VX661;VX661/Tezacaftor;VX-661 USP/EP/BP;VX 661; VX661;VX-661;VX 661;VX661;VX-661; TEZACAFTOR;Tezacaftor D4Q: What is Tezacaftor D4 Q: What is the CAS Number of Tezacaftor D4
CBNumber
CB22632076
Molecular Formula
C26H27F3N2O6
Formula Weight
520.5
MOL File
1152311-62-0.mol
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VX-661 Property

Boiling point:
610.8±55.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C , stored under nitrogen
solubility 
≥21.8 mg/mL in DMSO; insoluble in EtOH; ≥24.3 mg/mL in H2O
form 
solid
pka
13.99±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21480
Product name
VX-661
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
21480
Product name
VX-661
Purity
≥98%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
21480
Product name
VX-661
Purity
≥98%
Packaging
25mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
21480
Product name
VX-661
Purity
≥98%
Packaging
50mg
Price
$448
Updated
2024/03/01
TRC
Product number
T321510
Product name
Tezacaftor
Packaging
1mg
Price
$55
Updated
2021/12/16
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VX-661 Chemical Properties,Usage,Production

Description

Tezacaftor (VX-661) is an oral medication for cystic fibrosis (CF) developed by Vertex Pharmaceuticals. In a combination therapy formulation called Symdeko (tezacaftor plus ivacaftor), it is approved in the U.S. and Canada for CF patients, ages 12 and older, who have two copies of the F508del mutation in the CFTR gene and one minimal function mutation. Symdeko is approved and marketed in the EU as Symkevi.Tezacaftor is not approved as a stand-alone treatment, but as part of a combination therapy.

Uses

Tezacaftor is used as a combination therapy with Ivacaftor for the treatment of patients with cystic fibrosis.

Definition

VX-661 is an investigational compound that promotes the maturation of delta F508 mutants of the cystic fibrosis transmembrane conductance regulator (CFTR). Delta F508 CFTR represents a class of CFTR mutation that is characterized by impaired processing of misfolded CFTR proteins and reduced accumulation of the protein at the cell surface. VX-661 is intended to facilitate trafficking of CFTR to the epithelial cell membrane. It may be combined with the CFTR potentiator ivacaftor (Item No. 15145) to stimulate both CFTR accumulation and opening at the apical epithelial surface.

Biochem/physiol Actions

VX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis.

in vitro

VX-661, is CFTR modulator that is potentially useful for treatment of cystic fibrosis. VX-661 corrects F508del-CFTR trafficking and increases F508del-CFTR protein activity in vitro.

target

F508 del CFTR

References

[1] s. donaldson, j. pilewski, m. griese, q. dong, p.-s. lee, for the vx11–661-101 study group. ws7.3 vx-661, an investigational cftr corrector, in combination with ivacaftor, a cftr potentiator, in patients with cf and homozygous for the f508del-cftr mutation: interim analysis. journal of cystic fibrosis, volume 12, supplement 1, june 2013, page s14

VX-661 Preparation Products And Raw materials

Raw materials

Preparation Products

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VX-661 Suppliers

China 149 France 1 India 5 The Netherlands 1 United States 13 Global 169
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View Lastest Price from VX-661 manufacturers

Qiuxian Baitai New Material Co., LTD
Product
VX-661 1152311-62-0
Price
US $0.20/g
Min. Order
1KG
Purity
99%
Supply Ability
500ton/Month
Release date
2021-11-03
Wuhan Nutra Biotechnology Co.,Ltd
Product
tezacaftor;VX661 1152311-62-0
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1000kgs
Release date
2021-05-23
Career Henan Chemical Co
Product
VX-661 1152311-62-0
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100MT
Release date
2018-12-15

1152311-62-0, VX-661Related Search:

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  • VX 661;VX661;VX-661; TEZACAFTOR
  • VX-661
  • VX-661/VX661
  • 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide
  • (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxaMide
  • Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-
  • 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide VX661
  • 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide
  • (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-
  • VX 661; VX661;VX-661
  • VX661/Tezacaftor
  • CS-956
  • tezacaftor(VX661)
  • VX-661 USP/EP/BP
  • Tezacaftor D4Q: What is Tezacaftor D4 Q: What is the CAS Number of Tezacaftor D4
  • inhibit,Tezacaftor,Inhibitor,VX-661,Cystic fibrosis transmembrane conductance regulator,Autophagy,VX 661,CFTR
  • N,3,3-Trimethyl-1,5-dioxaspiro[5.5]undecan-9-amine Hydrochloride (4-Methylaminocyclohexanone 2',2'-Dimethyltrimethylene Ketal Hydrochloride)
  • 1152311-62-0
  • C26H27F3N2O6
  • Inhibitors
  • API