ChemicalBook > CAS DataBase List > Kinsenoside

Kinsenoside

Product Name
Kinsenoside
CAS No.
151870-74-5
Chemical Name
Kinsenoside
Synonyms
Kinsenoside;(+)-Kinsenoside;(4R)-4-(beta-D-Glucopyranosyloxy)dihydro-2(3H)-furanone;2(3H)-Furanone, 4-(β-D-glucopyranosyloxy)dihydro-, (4R)-;(4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one;(R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one;Keap1-Nrf2,Inhibitor,pulposus,disc,degeneration,Kinsenoside,inhibit,cells,nucleus,Nrf2,Apoptosis,intervertebral
CBNumber
CB22645474
Molecular Formula
C10H16O8
Formula Weight
264.23
MOL File
151870-74-5.mol
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Kinsenoside Property

Boiling point:
570.2±50.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMF:14.0(Max Conc. mg/mL);52.98(Max Conc. mM)
DMSO:33.0(Max Conc. mg/mL);124.89(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.85(Max Conc. mM)
form 
A crystalline solid
pka
12.81±0.70(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25144
Product name
Kinsenoside
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
25144
Product name
Kinsenoside
Purity
≥95%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
25144
Product name
Kinsenoside
Purity
≥95%
Packaging
10mg
Price
$341
Updated
2024/03/01
TRC
Product number
K570200
Product name
Kinsenoside
Packaging
10mg
Price
$420
Updated
2021/12/16
Usbiological
Product number
300531
Product name
Kinsenoside
Packaging
25mg
Price
$907
Updated
2021/12/16
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Kinsenoside Chemical Properties,Usage,Production

Description

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.

Uses

Kinsenoside is an anti-hyperlipidemic agent isolated from the plant Anoect chilus.

Definition

ChEBI: (3R)-5-Oxotetrahydro-3-furanyl beta-D-glucopyranoside is a glycoside.

Kinsenoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Kinsenoside Suppliers

China 105 United States 8 Global 113
Chengdu Push Bio-Technology Co., Ltd.
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View Lastest Price from Kinsenoside manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Kinsenoside 151870-74-5
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-04-24

151870-74-5, KinsenosideRelated Search:

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  • Kinsenoside
  • (4R)-4-(beta-D-Glucopyranosyloxy)dihydro-2(3H)-furanone
  • 2(3H)-Furanone, 4-(β-D-glucopyranosyloxy)dihydro-, (4R)-
  • (4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one
  • (+)-Kinsenoside
  • Keap1-Nrf2,Inhibitor,pulposus,disc,degeneration,Kinsenoside,inhibit,cells,nucleus,Nrf2,Apoptosis,intervertebral
  • (R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one
  • 151870-74-5