A 967079
- Product Name
- A 967079
- CAS No.
- 1170613-55-4
- Chemical Name
- A 967079
- Synonyms
- A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
- CBNumber
- CB22650391
- Molecular Formula
- C12H14FNO
- Formula Weight
- 207.24
- MOL File
- 1170613-55-4.mol
A 967079 Property
- Boiling point:
- 324.4±34.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥12mg/mL
- pka
- 12.23±0.40(Predicted)
- form
- powder
- color
- white to tan
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
- InChI
- InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
- InChIKey
- HKROEBDHHKMNBZ-CHBKHGQFSA-N
- SMILES
- C(/C1=CC=C(F)C=C1)=C(/C)\C(=N\O)\CC
Safety
- WGK Germany
- 3
- HS Code
- 2928009090
N-Bromosuccinimide Price
- Product number
- SML0085
- Product name
- A-967079
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- SML0085
- Product name
- A-967079
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $538
- Updated
- 2024/03/01
- Product number
- 15207
- Product name
- A-967079
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 15207
- Product name
- A-967079
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 15207
- Product name
- A-967079
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $286
- Updated
- 2024/03/01
A 967079 Chemical Properties,Usage,Production
Description
A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable
Uses
A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.
Uses
(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.
General Description
A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.
Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.
storage
+4°C
Advantages
(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime (A-967079) has shown impressive efficacy as an antagonist to TRPA1 and has multiple advantages over other compounds, including high selectivity, potency, and oral bioavailability. A-967079 has IC50 values of 67 and 289 nM for human and rat TRPA1 receptors, respectively. It displays 1000-fold selectivity for TRPA1 over other TRP channels, and >150-fold selectivity for over 75 other ion channels, enzymes and G-protein-coupled receptors. Oral administration of A-967079 in rats produced robust bioavailability and analgesic efficacy for TIH-induced pain response (i.e., sneezing, tearing, coughing, etc.) and osteoarthritic pain. Intravenous injection of A-967079 has shown to decrease the reactive gas response of wide dynamic range neurons (i.e., a second-order neuron that responds to more than one type of stimulus) and pain specific-neurons. Aditionally, A-967079 produces no known locomotor or cardiovascular effects, a common side effect of other TRP antagonists[2].
References
[1] McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.
[2] Obed A. Gyamfi . “Analysis of TRPA1 antagonist, A-967079, in plasma using high-performance liquid chromatography tandem mass-spectrometry.” Journal of Pharmaceutical Analysis 10 2 (2020): Pages 157-163.
A 967079 Preparation Products And Raw materials
Raw materials
Preparation Products
A 967079 Suppliers
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View Lastest Price from A 967079 manufacturers
- Product
- A 967079 1170613-55-4
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 99
- Supply Ability
- 20G
- Release date
- 2024-07-12