A 967079
- Product Name
- A 967079
- CAS No.
- 1170613-55-4
- Chemical Name
- A 967079
- Synonyms
- A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
- CBNumber
- CB22650391
- Molecular Formula
- C12H14FNO
- Formula Weight
- 207.24
- MOL File
- 1170613-55-4.mol
A 967079 Property
- Boiling point:
- 324.4±34.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥12mg/mL
- pka
- 12.23±0.40(Predicted)
- form
- powder
- color
- white to tan
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Safety
- WGK Germany
- 3
- HS Code
- 2928009090
N-Bromosuccinimide Price
- Product number
- SML0085
- Product name
- A-967079
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- SML0085
- Product name
- A-967079
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $538
- Updated
- 2024/03/01
- Product number
- 15207
- Product name
- A-967079
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 15207
- Product name
- A-967079
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 15207
- Product name
- A-967079
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $286
- Updated
- 2024/03/01
A 967079 Chemical Properties,Usage,Production
Description
A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable
Uses
A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.
Uses
(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.
General Description
A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.
Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.
storage
+4°C
References
1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.