WEHI-539

Product Name: WEHI-539
CAS No.: 1431866-33-9
Chemical Name: WEHI-539
Synonyms: CS-1739;WEHI-539;WEHI539;WEHI 539;WEHI-539 ( CT-WE539);(E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr;5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid;5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid;4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-;(E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
CBNumber: CB22655422
Molecular Formula: C31H29N5O3S2
Formula Weight: 583.72
MOL File: 1431866-33-9.mol

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WEHI-539 Property

Boiling point:: 827.6±75.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 10.24±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21478
Product name: WEHI-539
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21478
Product name: WEHI-539
Purity: ≥98%
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Cayman Chemical

Product number: 21478
Product name: WEHI-539
Purity: ≥98%
Packaging: 10mg
Price: $412
Updated: 2024/03/01

TRC

Product number: W498725
Product name: WEHI539
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

ApexBio Technology

Product number: A3935
Product name: WEHI-539
Packaging: 50mg
Price: $955
Updated: 2021/12/16

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WEHI-539 Chemical Properties,Usage,Production

Uses

WEHI 539 is a selective BCL-XL inhibitor.

Biological Activity

wehi-539 is a small-molecule inhibitor of bclxlwith an ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xlinhibitor with high affinity. it interacted the with the binding groove of bcl-xlwith a kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. in bcl-xloverexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539can not kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xland mcl-1. [1].

target

BCL-XL

References

[1] lessene g, czabotar p e, sleebs b e, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397.

WEHI-539 Preparation Products And Raw materials

Raw materials

Preparation Products

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WEHI-539 Suppliers

China 57 United States 14 Global 71

MedChemexpress LLC

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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TargetMol Chemicals Inc.

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Cayman Chemical Company

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Creative Enzymes

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ChemieTek

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1431866-33-9, WEHI-539Related Search:

4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WEHI-345 WEHI-539 HCl WEHI-345 (analog)

WEHI-539

(E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid

WEHI-539 ( CT-WE539)

5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid

(E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr

CS-1739

WEHI539;WEHI 539

4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-

5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid

1431866-33-9

C31H29N5O3S2