AT-101

Product Name: AT-101
CAS No.: 866541-93-7
Chemical Name: AT-101
Synonyms: AT101 acetate;AT-101 (AT101);AT-101 USP/EP/BP;AT-101 (acetic acid);(-)-Gossypol acetic acid;Gossypol acetic acid Bcl-2 inhibitor AT101 AT-101;(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid));Bcl-2 Family,Autophagy,(R) ( ) Gossypol acetic acid,Inhibitor,(R)()Gossypol acetic acid,inhibit;(R)-1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde acetic acid salt;[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)
CBNumber: CB22658180
Molecular Formula: C32H34O10
Formula Weight: 578.60636
MOL File: 866541-93-7.mol

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AT-101 Property

storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO : 39.33 mg/mL (67.97 mM)
form: Solid
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0004767
Product name: [2,2'-BINAPHTHALENE]-8,8'-DICARBOXALDEHYDE, 1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-5,5'-BIS(1-METHYLETHYL)-, (2R)-, COMPD. WITH ACETIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $502.72
Updated: 2021/12/16

DC Chemicals

Product number: DC2015
Product name: AT-101(AT101)
Purity: >98%
Packaging: 250mg
Price: $800
Updated: 2021/12/16

DC Chemicals

Product number: DC2015
Product name: AT-101(AT101)
Purity: >98%
Packaging: 1g
Price: $1600
Updated: 2021/12/16

CSNpharm

Product number: CSN18501
Product name: AT-101AceticAcid
Packaging: 1mg
Price: $50
Updated: 2021/12/16

CSNpharm

Product number: CSN18501
Product name: AT-101AceticAcid
Packaging: 5mg
Price: $71
Updated: 2021/12/16

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AT-101 Chemical Properties,Usage,Production

Biological Activity

AT-101, the R-(-) enantiomer of Gossypol acetic acid, binds to Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.32 μM, 0.48 μM and 0.18 μM; no Inhibits the BIR3 domain and BID. Phase 2.

in vitro

AT-101 inhibits a diverse panel of lymphoproliferative malignancies with IC50 of 1.2 μM to 7.4 μM after 24 hours of treatment, 0.7 μM to 3.9 μM after 48 hours of treatment, IC50 of 72 hours after treatment 0.3 μM to 1.7 μM. AT-101 (10 μM) disrupts mitochondrial membrane potential (Δψm) in a concentration- and time-dependent manner in diffuse large B-cell and mantle cell lymphoma cell lines.

in vivo

AT-101 treated SCID beige mice bearing RL-DLBCL xenografts, it was still detectable in plasma, with a mean concentration of 0.49 μM in the 35 mg/kg group and 0.39 μM in the 200 mg/kg group . In SCID beige mice treated with it, peak plasma concentrations were observed after 30 minutes, and the mean plasma concentration in the 200 mg/kg group was almost 4-fold higher than that in the 35 mg/kg group (7.88 μM and 27.78 μM, respectively).

target

td>

Target	Value
Mcl-1 (Cell-free assay)	0.18 μM(Ki)
Bcl-2 (Cell-free assay)	0.32 μM(Ki)
Bcl-xL (Cell-free assay)	0.48 μM(Ki)

AT-101 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT-101 Suppliers

China 66 United States 11 Global 77

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Nanjing Peiwill Biotechnology Co.,Ltd.

Tel: 025-57027729 15850702895
Fax: 025-57027729
Email: 15850702895@163.com
Country: China
ProdList: 73
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

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View Lastest Price from AT-101 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: AT-101 866541-93-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

866541-93-7, AT-101Related Search:

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[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)

AT-101 [2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. wi

AT-101 (acetic acid)

AT101 acetate

AT-101 (AT101)

AT-101 USP/EP/BP

(-)-Gossypol acetic acid

(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

Gossypol acetic acid Bcl-2 inhibitor AT101 AT-101

Bcl-2 Family,Autophagy,(R) ( ) Gossypol acetic acid,Inhibitor,(R)()Gossypol acetic acid,inhibit

(R)-1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde acetic acid salt

866541-93-7

Inhibitor

Inhibitors