AT-101
- Product Name
- AT-101
- CAS No.
- 866541-93-7
- Chemical Name
- AT-101
- Synonyms
- AT101 acetate;AT-101 (AT101);AT-101 USP/EP/BP;AT-101 (acetic acid);(-)-Gossypol acetic acid;Gossypol acetic acid Bcl-2 inhibitor AT101 AT-101;(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid));Bcl-2 Family,Autophagy,(R) ( ) Gossypol acetic acid,Inhibitor,(R)()Gossypol acetic acid,inhibit;(R)-1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde acetic acid salt;[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)
- CBNumber
- CB22658180
- Molecular Formula
- C32H34O10
- Formula Weight
- 578.60636
- MOL File
- 866541-93-7.mol
AT-101 Property
- storage temp.
- Store at -20°C, protect from light, stored under nitrogen
- solubility
- DMSO : 39.33 mg/mL (67.97 mM)
- form
- Solid
- color
- Light yellow to brown
N-Bromosuccinimide Price
- Product number
- INB0004767
- Product name
- [2,2'-BINAPHTHALENE]-8,8'-DICARBOXALDEHYDE, 1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-5,5'-BIS(1-METHYLETHYL)-, (2R)-, COMPD. WITH ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.72
- Updated
- 2021/12/16
- Product number
- DC2015
- Product name
- AT-101(AT101)
- Purity
- >98%
- Packaging
- 250mg
- Price
- $800
- Updated
- 2021/12/16
- Product number
- DC2015
- Product name
- AT-101(AT101)
- Purity
- >98%
- Packaging
- 1g
- Price
- $1600
- Updated
- 2021/12/16
- Product number
- CSN18501
- Product name
- AT-101AceticAcid
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CSN18501
- Product name
- AT-101AceticAcid
- Packaging
- 5mg
- Price
- $71
- Updated
- 2021/12/16
AT-101 Chemical Properties,Usage,Production
Biological Activity
AT-101, the R-(-) enantiomer of Gossypol acetic acid, binds to Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; no Inhibits the BIR3 domain and BID. Phase 2.
in vitro
AT-101 inhibits a diverse panel of lymphoproliferative malignancies with IC50 of 1.2 μM to 7.4 μM after 24 hours of treatment, 0.7 μM to 3.9 μM after 48 hours of treatment, IC50 of 72 hours after treatment 0.3 μM to 1.7 μM. AT-101 (10 μM) disrupts mitochondrial membrane potential (Δψm) in a concentration- and time-dependent manner in diffuse large B-cell and mantle cell lymphoma cell lines.
in vivo
AT-101 treated SCID beige mice bearing RL-DLBCL xenografts, it was still detectable in plasma, with a mean concentration of 0.49 μM in the 35 mg/kg group and 0.39 μM in the 200 mg/kg group . In SCID beige mice treated with it, peak plasma concentrations were observed after 30 minutes, and the mean plasma concentration in the 200 mg/kg group was almost 4-fold higher than that in the 35 mg/kg group (7.88 μM and 27.78 μM, respectively).
target
Target | Value |
Mcl-1 (Cell-free assay) | 0.18 μM(Ki) |
Bcl-2 (Cell-free assay) | 0.32 μM(Ki) | td>
Bcl-xL (Cell-free assay) | 0.48 μM(Ki) |
AT-101 Preparation Products And Raw materials
Raw materials
Preparation Products
AT-101 Suppliers
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View Lastest Price from AT-101 manufacturers
- Product
- AT-101 866541-93-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22