Abacavir Related CoMpound D

Product Name: Abacavir Related CoMpound D
CAS No.: 1443421-69-9
Chemical Name: Abacavir Related CoMpound D
Synonyms: Abacavir EP Imp B;Abacavir Impurity B;Abacavir Impurity D;Abacavir EP Impurity B;ABACAVIR O-PYRIMIDYL IMP;Abacavir Related CoMpound D;O-Pyrimidine Derivative Abacavir (USP);Abacavir Impurity 2(Abacavir EP Impurity B);Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine;N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine
CBNumber: CB22714699
Molecular Formula: C18H21ClN10O
Formula Weight: 428.88
MOL File: 1443421-69-9.mol

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Abacavir Related CoMpound D Property

Boiling point:: 830.1±75.0 °C(Predicted)
Density: 1.90±0.1 g/cm3(Predicted)
pka: 4.86±0.10(Predicted)

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Safety

WGK Germany: 3
HS Code: 2933599550

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1000437
Product name: Abacavir Related Compound D
Packaging: 20mg
Price: $1360
Updated: 2024/03/01

TRC

Product number: A105035
Product name: Abacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine
Packaging: 25mg
Price: $1050
Updated: 2021/12/16

TRC

Product number: A105035
Product name: Abacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine
Packaging: 2.5mg
Price: $130
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0027217
Product name: ABACAVIR O-PYRIMIDINE IMPURITY
Purity: 95.00%
Packaging: 5MG
Price: $504.96
Updated: 2021/12/16

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Abacavir Related CoMpound D Chemical Properties,Usage,Production

Uses

Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir Related CoMpound D Preparation Products And Raw materials

Raw materials

Preparation Products

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Abacavir Related CoMpound D Suppliers

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1443421-69-9, Abacavir Related CoMpound DRelated Search:

Abacavir sulfate 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- Abacavir (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride 6-aminocarbovir Abacavir-d4 Abacavir Abacavir trans-Abacavir Hydrochloride 2-Amino-6-cyclopropylamino-9H-purine (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol 2,6-Diaminopurine Abacavir 5'-Glucuronide Abacavir Abacavir Carboxylate Abacavir 5’-Phosphate (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride Abacavir Impurity 1

Abacavir EP Imp B

Abacavir Related CoMpound D

N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine

Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine

Abacavir Impurity 2(Abacavir EP Impurity B)

Abacavir EP Impurity B

O-Pyrimidine Derivative Abacavir (USP)

6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine

9H-Purine-2,6-diamine, N6-cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4-pyrimidinyl)oxy]methyl]-2-cyclopenten-1-yl]-

Abacavir Impurity D

Abacavir Impurity B

6-N-Cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4- pyrimidinyl)oxy]methyl]cyclopent-2-en-1-yl]-9H-purine-2,6- diamine

ABACAVIR O-PYRIMIDYL IMP

N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-Diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine (Abacavir Impurity)

Abacavir Related Compound D (20 mg) (N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine)

1443421-69-9

C18H21ClN10O