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Abacavir Related CoMpound D

Product Name
Abacavir Related CoMpound D
CAS No.
1443421-69-9
Chemical Name
Abacavir Related CoMpound D
Synonyms
Abacavir EP Imp B;Abacavir Impurity B;Abacavir Impurity D;Abacavir EP Impurity B;ABACAVIR O-PYRIMIDYL IMP;Abacavir Related CoMpound D;O-Pyrimidine Derivative Abacavir (USP);Abacavir Impurity 2(Abacavir EP Impurity B);Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine;N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine
CBNumber
CB22714699
Molecular Formula
C18H21ClN10O
Formula Weight
428.88
MOL File
1443421-69-9.mol
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Abacavir Related CoMpound D Property

Boiling point:
830.1±75.0 °C(Predicted)
Density 
1.90±0.1 g/cm3(Predicted)
pka
4.86±0.10(Predicted)
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Safety

WGK Germany 
3
HS Code 
2933599550
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1000437
Product name
Abacavir Related Compound D
Packaging
20mg
Price
$1360
Updated
2024/03/01
TRC
Product number
A105035
Product name
Abacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine
Packaging
25mg
Price
$1050
Updated
2021/12/16
TRC
Product number
A105035
Product name
Abacavir5’-4-Chloro-6-methylpyrimidine-2,5-diamine
Packaging
2.5mg
Price
$130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027217
Product name
ABACAVIR O-PYRIMIDINE IMPURITY
Purity
95.00%
Packaging
5MG
Price
$504.96
Updated
2021/12/16
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Abacavir Related CoMpound D Chemical Properties,Usage,Production

Uses

Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir Related CoMpound D Preparation Products And Raw materials

Raw materials

Preparation Products

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Abacavir Related CoMpound D Suppliers

China 25 India 7 United States 4 Global 36
Olympus Chemicals & Fertilizers
Tel
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Fax
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Country
India
ProdList
486
Advantage
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1443421-69-9, Abacavir Related CoMpound DRelated Search:

Abacavir sulfate 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- Abacavir (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride 6-aminocarbovir Abacavir-d4 Abacavir Abacavir trans-Abacavir Hydrochloride 2-Amino-6-cyclopropylamino-9H-purine (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol 2,6-Diaminopurine Abacavir 5'-Glucuronide Abacavir Abacavir Carboxylate Abacavir 5’-Phosphate (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride Abacavir Impurity 1

  • Abacavir EP Imp B
  • Abacavir Related CoMpound D
  • N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine
  • Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine
  • Abacavir Impurity 2(Abacavir EP Impurity B)
  • Abacavir EP Impurity B
  • O-Pyrimidine Derivative Abacavir (USP)
  • 6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine
  • 9H-Purine-2,6-diamine, N6-cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4-pyrimidinyl)oxy]methyl]-2-cyclopenten-1-yl]-
  • Abacavir Impurity D
  • Abacavir Impurity B
  • 6-N-Cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4- pyrimidinyl)oxy]methyl]cyclopent-2-en-1-yl]-9H-purine-2,6- diamine
  • ABACAVIR O-PYRIMIDYL IMP
  • N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-Diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine (Abacavir Impurity)
  • Abacavir Related Compound D (20 mg) (N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine)
  • 1443421-69-9
  • C18H21ClN10O