AZ191
- Product Name
- AZ191
- CAS No.
- 1594092-37-1
- Chemical Name
- AZ191
- Synonyms
- AZ191;CS-1824;AZ-191;AZ 191;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine;2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-;[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine;Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191
- CBNumber
- CB22716123
- Molecular Formula
- C24H27N7O
- Formula Weight
- 429.52
- MOL File
- 1594092-37-1.mol
AZ191 Property
- Boiling point:
- 705.3±70.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- pka
- 7.76±0.42(Predicted)
- color
- white to yellow to light brown
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H301Toxic if swalloed
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 17693
- Product name
- AZ191
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17693
- Product name
- AZ191
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 17693
- Product name
- AZ191
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- 17693
- Product name
- AZ191
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 5232
- Product name
- AZ191
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $836
- Updated
- 2021/12/16
AZ191 Chemical Properties,Usage,Production
Uses
AZ191 is a potent and selective DYRK1B inhibitor (1).
Enzyme inhibitor
This potent and selective DYRK inhibitor (FW = 429.53 g/mol), also systematically named N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4- (1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, selectively targets DYRK1B, a Dual specificity tyrosine-phosphorylation-regulated kinase, with an IC50 value of 17 nM, or about 5x and 110x higher affinity than for DYRK1A and DYRK2. AZ191 is effective both in vitro and in cells. DYRK1B has also been proposed to promote the turnover of Cyclin D1, a key regulator of mammalian G1-S-phase transitions. Cyclin D1 is phosphorylated on Thr-286 by GSK3β (or glycogen synthase kinase 3β), thereby promoting its degradation.
storage
Store at -20°C
AZ191 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ191 Suppliers
View Lastest Price from AZ191 manufacturers
- Product
- AZ191 1594092-37-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20