K-Ras(G12C) inhibitor 6

Product Name: K-Ras(G12C) inhibitor 6
CAS No.: 2060530-16-5
Chemical Name: K-Ras(G12C) inhibitor 6
Synonyms: CS-2013;MDK30165;K-Ras(G12C) inhibitor 6;K-Ras(G12C) inhibitor 6 USP/EP/BP;N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide;Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-;N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide;Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6
CBNumber: CB22728650
Molecular Formula: C17H22Cl2N2O3S
Formula Weight: 405.34
MOL File: 2060530-16-5.mol

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K-Ras(G12C) inhibitor 6 Property

Boiling point:: 643.4±55.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥20.25 mg/mL in DMSO
form: solid
pka: 10.21±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D438295
Product name: N-[1-[2-(2,4-Dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-butanamide
Packaging: 10mg
Price: $470
Updated: 2021/12/16

ApexBio Technology

Product number: B3694
Product name: K-Ras(G12C)inhibitor6
Packaging: 10mM(in 1mL DMSO)
Price: $130
Updated: 2021/12/16

ApexBio Technology

Product number: B3694
Product name: K-Ras(G12C)inhibitor6
Packaging: 10mg
Price: $200
Updated: 2021/12/16

ApexBio Technology

Product number: B3694
Product name: K-Ras(G12C)inhibitor6
Packaging: 25mg
Price: $420
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181272
Product name: K-Ras(G12C) inhibitor 6
Purity: >98%
Packaging: 100mg
Price: $765
Updated: 2021/12/16

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K-Ras(G12C) inhibitor 6 Chemical Properties,Usage,Production

Uses

N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide is an irreversible and allosteric inhibitor of the K-Ras(G12C) mutant. This compound has potential therapeutic application for diseases related to Ras signaling.

Biological Activity

k-ras (g12c) inhibitor 6 is an allosterical inhibitor of oncogenic mutation k-ras g12c [1].k-ras (g12c) inhibitor 6 is a cysteine-reactive small molecule. it irreversibly binds to the g12c mutantion of gtpase k-ras but not the wild-type k-ras with the relative potency value of 4.2. the binding pocket of k-ras for k-ras (g12c) inhibitor 6 is a new allosteric pocket, s-iip. binding of this pocket results in a change of the relative nucleotide affinity of ras to favour gdp over gtp, leading to an accumulation of inactive ras. since the mutation of k-ras is quite common in human cancers, the inhibitor of k-ras g12c should exert suppression activities in tumor cells. it has been reported that, some of the k-ras g12c inhibitors are indeed effective to decrease cell viability and increase apoptosis in lung cancer cell lines [1].

References

[1] ostrem j m, peters u, sos m l, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions. nature, 2013, 503(7477): 548-551.

K-Ras(G12C) inhibitor 6 Preparation Products And Raw materials

Raw materials

Preparation Products

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K-Ras(G12C) inhibitor 6 Suppliers

China 51 United States 9 USA 1 Global 61

AdooQ BioScience, LLC

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View Lastest Price from K-Ras(G12C) inhibitor 6 manufacturers

Career Henan Chemical Co

Product: K-Ras(G12C) inhibitor 6 2060530-16-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

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K-Ras(G12C) inhibitor 6

N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide

CS-2013

MDK30165

Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-

K-Ras(G12C) inhibitor 6 USP/EP/BP

N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide

Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6

2060530-16-5

Inhibitors

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