ChemicalBook > CAS DataBase List > FLLL31

FLLL31

Product Name
FLLL31
CAS No.
52328-97-9
Chemical Name
FLLL31
Synonyms
FLLL31;FLLL31 >=98% (HPLC);Tetramethylcurcumin;FLLL31;FLLL-31;FLLL 31;Tetramethylcurcumin（FLLL31）;Tetramethylcurcumin, 10 mM in DMSO;(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-
CBNumber
CB22731058
Molecular Formula
C25H28O6
Formula Weight
424.49
MOL File
52328-97-9.mol
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FLLL31 Property

Boiling point:
594.5±50.0 °C(Predicted)
Density 
1.140±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F9057
Product name
FLLL31
Purity
≥98% (HPLC)
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
F9057
Product name
FLLL31
Purity
≥98% (HPLC)
Packaging
25mg
Price
$436
Updated
2024/03/01
Usbiological
Product number
301048
Product name
Tetramethylcurcumin
Packaging
20mg
Price
$665
Updated
2021/12/16
Biorbyt Ltd
Product number
orb259527
Product name
Tetramethylcurcumin
Purity
98%
Packaging
20mg
Price
$596.7
Updated
2021/12/16
ChemScene
Product number
CS-0022792
Product name
Tetramethylcurcumin
Packaging
5mg
Price
$235
Updated
2021/12/16
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FLLL31 Chemical Properties,Usage,Production

Biological Activity

Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.

in vitro

Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.

target

STAT3

FLLL31 Preparation Products And Raw materials

Raw materials

Preparation Products

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FLLL31 Suppliers

China 68 United States 5 Global 73
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

52328-97-9, FLLL31Related Search:

2,2-DIMETHYLTETRAHYDROFURAN Curcumin (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL DihydrocurcuMin 5"-MethoxyhexahydrocurcuMin BIS(4-HYDROXYCINNAMOYL)METHANE Tetrahydrocurcumin HEXAHYDROCURCUMIN DEMETHOXYCURCUMIN ASC-J9

  • FLLL31
  • Tetramethylcurcumin
  • (E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione
  • (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione
  • FLLL31;FLLL-31;FLLL 31
  • 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-
  • FLLL31 >=98% (HPLC)
  • (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione
  • pancreatic,FLLL-31,domain,FLLL 31,Apoptosis,Inhibitor,STAT,Tetramethylcurcumin,cancer,kinase,Curcumin,Janus,Src,anti-inflammatory,FLLL31,breast,inhibit,homology-2
  • Tetramethylcurcumin（FLLL31）
  • Tetramethylcurcumin, 10 mM in DMSO
  • 52328-97-9