HEXAHYDROCURCUMIN

Product Name: HEXAHYDROCURCUMIN
CAS No.: 36062-05-2
Chemical Name: HEXAHYDROCURCUMIN
Synonyms: HEXAHYDROCURCUMIN;Hexahydrocurcumin-RM;Hexahydrocurcumin, BR;5-dimethyl ether Gallic Acid;Hexahydrocurcumin, 10 mM in DMSO;5-dimethoxy-4-hydroxy Benzoic Acid;5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyheptan-3-one;1,7-Bis(3-methoxy-4-hydroxyphenyl)-5-hydroxy-3-heptanone;5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one
CBNumber: CB41412369
Molecular Formula: C21H26O6
Formula Weight: 374.43
MOL File: 36062-05-2.mol

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HEXAHYDROCURCUMIN Property

Melting point:: 80-82℃
Boiling point:: 622.6±55.0 °C(Predicted)
Density: 1.226
Flash point:: 218℃
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly), DCM, DMSO
form: Solid
pka: 10.02±0.20(Predicted)
color: Pale Yellow
BRN: 2486876

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB01366
Product name: Hexahydrocurcumin
Purity: ≥95% (HPLC)
Packaging: 1MG
Price: $128
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB01366
Product name: Hexahydrocurcumin
Purity: ≥95% (HPLC)
Packaging: 10MG
Price: $765
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL82559
Product name: Hexahydrocurcumin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $910
Updated: 2025/07/31

Sigma-Aldrich

Product number: 69727
Product name: Hexahydrocurcumin
Purity: analytical standard
Packaging: 10mg
Price: $860
Updated: 2025/07/31

Cayman Chemical

Product number: 11714
Product name: Hexahydrocurcumin
Purity: ≥95%
Packaging: 1mg
Price: $86
Updated: 2024/03/01

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HEXAHYDROCURCUMIN Chemical Properties,Usage,Production

Description

Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties. It reduces prostaglandin E₂ (PGE₂) production stimulated by phorbol 12-myristate 13-acetate (PMA; ) by 37% in human colonic epithelial cells when used at a concentration of 20 μM. Hexahydrocurcumin (3.125-25 μM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner. It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 μM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil .

Uses

Hexahydrocurcumin is an intermediate in the synthesis of Gingerenone A (G387500) which is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.

Definition

ChEBI: Hexahydrocurcumin is a diarylheptanoid.

in vivo

Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats^[3].

Animal Model:	Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH)^[3]
Dosage:	50 mg/kg
Administration:	Oral administration; daily; for 16 weeks
Result:	Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression.

target

PGE | NOS | COX

IC 50

COX-2

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] FENG ZHAO. Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: translocation of nuclear factor-κB as potential target.[J]. Molecular medicine reports, 2015: 3087-3093. DOI: 10.3892/mmr.2014.3079
[3] KHANITTA SRIMUANGWONG. Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats.[J]. World Journal of Gastroenterology, 2012, 18 47: 6951-6959. DOI: 10.3748/wjg.v18.i47.6951

HEXAHYDROCURCUMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HEXAHYDROCURCUMIN Suppliers

China 143 India 1 United States 10 Global 154

Chengdu DeSiTe Biological Technology Co., Ltd

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View Lastest Price from HEXAHYDROCURCUMIN manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: HEXAHYDROCURCUMIN 36062-05-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shanghai Standard Technology Co., Ltd.

Product: Hexahydrocurcumin 36062-05-2
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-09

36062-05-2, HEXAHYDROCURCUMINRelated Search:

Phosphorus pentachloride CHEBULAE FRUCTUS IMMATURUS DEMETHOXYCURCUMIN BIS(4-HYDROXYCINNAMOYL)METHANE 5"-MethoxyhexahydrocurcuMin (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL FLLL31 DihydrocurcuMin Curcumin ASC-J9 Tetrahydrocurcumin TetrahydrocucuMin Hexahydropyridazin

HEXAHYDROCURCUMIN

5-Hydroxy-1-(4-hydroxy-3-Methoxycyclohexyl)-7-(4-hydroxy-3-Methoxyphenyl)heptan-3-one

(RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone

1,7-Bis(3-methoxy-4-hydroxyphenyl)-5-hydroxy-3-heptanone

1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyheptan-3-one

5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone

Hexahydrocurcumin, BR

3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-

5-dimethoxy-4-hydroxy Benzoic Acid

5-dimethyl ether Gallic Acid

5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one

Hexahydrocurcumin-RM

Hexahydrocurcumin, 10 mM in DMSO

Hexahydro curcumin: (RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone

36062-05-2