DEMETHOXYCURCUMIN

Product Name: DEMETHOXYCURCUMIN
CAS No.: 22608-11-3
Chemical Name: DEMETHOXYCURCUMIN
Synonyms: emethoxycurcumin;Demethoxycurcumin;Curcumin Desmethoxy;Demethoxycurcumin-RM;DEMETHOXYCURCUMIN(SH);MonodeMethoxycurcuMin;Z/E-Desmethoxycurcumin;Demethoxycurcumin (AS);(2E)-DeMethoxy CurcuMin;(E,E)-demethoxycurcumin
CBNumber: CB0960423
Molecular Formula: C20H18O5
Formula Weight: 338.35
MOL File: 22608-11-3.mol

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DEMETHOXYCURCUMIN Property

Melting point:: 166～170℃
Boiling point:: 571.4±50.0 °C(Predicted)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
form: powder
pka: 8.31±0.46(Predicted)
color: orange
LogP: 3.113 (est)

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 2
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D7696
Product name: Demethoxycurcumin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $100.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 90593
Product name: Demethoxycurcumin
Purity: analytical standard
Packaging: 10mg
Price: $387
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1173100
Product name: Desmethoxycurcumin
Purity: UnitedStatesPharmacopeia(USP)ReferenceStandard
Packaging: 30mg
Price: $394
Updated: 2024/03/01

Cayman Chemical

Product number: 10961
Product name: Demethoxycurcumin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10961
Product name: Demethoxycurcumin
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

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DEMETHOXYCURCUMIN Chemical Properties,Usage,Production

Uses

The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.

Uses

Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.

Definition

ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.

DEMETHOXYCURCUMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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DEMETHOXYCURCUMIN Suppliers

Canada 1 China 155 Germany 1 India 6 Japan 1 United Kingdom 2 United States 18 USA 1 Global 185

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
ProdList: 297
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
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Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

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View Lastest Price from DEMETHOXYCURCUMIN manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Demethoxycurcumin 22608-11-3
Price: US $55.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-26

Shanghai Standard Technology Co., Ltd.

Product: Demethoxycurcumin 22608-11-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: DEMETHOXYCURCUMIN 22608-11-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

22608-11-3, DEMETHOXYCURCUMINRelated Search:

Tetrahydrocurcumin 5"-MethoxyhexahydrocurcuMin BIS(4-HYDROXYCINNAMOYL)METHANE (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL DihydrocurcuMin ASC-J9 HEXAHYDROCURCUMIN FLLL31 lithospermic acid 13,14-Didehydromatridin-15-one Curcumin BIS(4-HYDROXYCINNAMOYL)METHANE DEMETHOXYCURCUMIN CURCUMIN, [3H]- CURCUMIN DIACETATE

Feruloyl-P-hydroxycinnnamoylmethane

MonodeMethoxycurcuMin

(1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-Methoxyphenyl)-1,6-heptadiene-3,5-d

(E,E)-1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione

1-(4-Hydroxy-3-Methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione

DeMethoxyCurcuMin(DesMethoxycurcuMin)

p-HydroxycinnaMoylferuloylMethane

Demethoxycurcumin

1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione

1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-

DEMETHOXYCURCUMIN(SH)

(2E)-DeMethoxy CurcuMin

Demethoxycurcumin, 98%, from Curcuma longa L.

(1E,6E)-Demethoxycurcumin

Z/E-Desmethoxycurcumin

1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-

Curcumin Desmethoxy

DEMETHOXYCURCUMIN USP/EP/BP

(E,E)-demethoxycurcumin

Demethoxycurcumin (Mixture of Isomers)

emethoxycurcumin

Demethoxycurcumin (AS)

Curcumin II|||Desmethoxycurcumin|||Monodemethoxycurcumin

Demethoxycurcumin-RM

22608-11-3

33173-16-3

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