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DEMETHOXYCURCUMIN

Product Name
DEMETHOXYCURCUMIN
CAS No.
22608-11-3
Chemical Name
DEMETHOXYCURCUMIN
Synonyms
emethoxycurcumin;Demethoxycurcumin;Curcumin Desmethoxy;Demethoxycurcumin-RM;DEMETHOXYCURCUMIN(SH);MonodeMethoxycurcuMin;Z/E-Desmethoxycurcumin;Demethoxycurcumin (AS);(2E)-DeMethoxy CurcuMin;(E,E)-demethoxycurcumin
CBNumber
CB0960423
Molecular Formula
C20H18O5
Formula Weight
338.35
MOL File
22608-11-3.mol
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DEMETHOXYCURCUMIN Property

Melting point:
166～170℃
Boiling point:
571.4±50.0 °C(Predicted)
Density 
1.282±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
pka
8.31±0.46(Predicted)
color 
orange
LogP
3.113 (est)
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Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7696
Product name
Demethoxycurcumin
Purity
≥98% (HPLC)
Packaging
5mg
Price
$100.8
Updated
2024/03/01
Sigma-Aldrich
Product number
90593
Product name
Demethoxycurcumin
Purity
analytical standard
Packaging
10mg
Price
$387
Updated
2024/03/01
Sigma-Aldrich
Product number
1173100
Product name
Desmethoxycurcumin
Purity
UnitedStatesPharmacopeia(USP)ReferenceStandard
Packaging
30mg
Price
$394
Updated
2024/03/01
Cayman Chemical
Product number
10961
Product name
Demethoxycurcumin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10961
Product name
Demethoxycurcumin
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
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DEMETHOXYCURCUMIN Chemical Properties,Usage,Production

Uses

The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.

Uses

Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.

Definition

ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.

DEMETHOXYCURCUMIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DEMETHOXYCURCUMIN manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Demethoxycurcumin 22608-11-3
Price
US $55.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-26
Shanghai Standard Technology Co., Ltd.
Product
Demethoxycurcumin 22608-11-3
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-22
Zhuozhou Wenxi import and Export Co., Ltd
Product
DEMETHOXYCURCUMIN 22608-11-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

22608-11-3, DEMETHOXYCURCUMINRelated Search:

Tetrahydrocurcumin 5"-MethoxyhexahydrocurcuMin BIS(4-HYDROXYCINNAMOYL)METHANE (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL DihydrocurcuMin ASC-J9 HEXAHYDROCURCUMIN FLLL31 lithospermic acid 13,14-Didehydromatridin-15-one Curcumin BIS(4-HYDROXYCINNAMOYL)METHANE DEMETHOXYCURCUMIN CURCUMIN, [3H]- CURCUMIN DIACETATE

  • Feruloyl-P-hydroxycinnnamoylmethane
  • MonodeMethoxycurcuMin
  • (1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-Methoxyphenyl)-1,6-heptadiene-3,5-d
  • (E,E)-1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • 1-(4-Hydroxy-3-Methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • DeMethoxyCurcuMin(DesMethoxycurcuMin)
  • p-HydroxycinnaMoylferuloylMethane
  • Demethoxycurcumin
  • 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
  • 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-
  • DEMETHOXYCURCUMIN(SH)
  • (2E)-DeMethoxy CurcuMin
  • Demethoxycurcumin, 98%, from Curcuma longa L.
  • (1E,6E)-Demethoxycurcumin
  • Z/E-Desmethoxycurcumin
  • 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-
  • Curcumin Desmethoxy
  • DEMETHOXYCURCUMIN USP/EP/BP
  • (E,E)-demethoxycurcumin
  • Demethoxycurcumin (Mixture of Isomers)
  • emethoxycurcumin
  • Demethoxycurcumin (AS)
  • Curcumin II|||Desmethoxycurcumin|||Monodemethoxycurcumin
  • Demethoxycurcumin-RM
  • Demethoxycurcumin, 10 mM in DMSO
  • 22608-11-3
  • 33173-16-3
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals