DEMETHOXYCURCUMIN
- Product Name
- DEMETHOXYCURCUMIN
- CAS No.
- 22608-11-3
- Chemical Name
- DEMETHOXYCURCUMIN
- Synonyms
- emethoxycurcumin;Demethoxycurcumin;Curcumin Desmethoxy;DEMETHOXYCURCUMIN(SH);MonodeMethoxycurcuMin;Z/E-Desmethoxycurcumin;Demethoxycurcumin (AS);(2E)-DeMethoxy CurcuMin;(E,E)-demethoxycurcumin;(1E,6E)-Demethoxycurcumin
- CBNumber
- CB0960423
- Molecular Formula
- C20H18O5
- Formula Weight
- 338.35
- MOL File
- 22608-11-3.mol
DEMETHOXYCURCUMIN Property
- Melting point:
- 166～170℃
- Boiling point:
- 571.4±50.0 °C(Predicted)
- Density
- 1.282±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- pka
- 8.31±0.46(Predicted)
- color
- orange
- LogP
- 3.113 (est)
N-Bromosuccinimide Price
- Product number
- D7696
- Product name
- Demethoxycurcumin
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $100.8
- Updated
- 2024/03/01
- Product number
- 90593
- Product name
- Demethoxycurcumin
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $387
- Updated
- 2024/03/01
- Product number
- 1173100
- Product name
- Desmethoxycurcumin
- Purity
- UnitedStatesPharmacopeia(USP)ReferenceStandard
- Packaging
- 30mg
- Price
- $394
- Updated
- 2024/03/01
- Product number
- 10961
- Product name
- Demethoxycurcumin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 10961
- Product name
- Demethoxycurcumin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
DEMETHOXYCURCUMIN Chemical Properties,Usage,Production
Uses
The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300.
Uses
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.
Definition
ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.
DEMETHOXYCURCUMIN Preparation Products And Raw materials
Raw materials
Preparation Products
DEMETHOXYCURCUMIN Suppliers
View Lastest Price from DEMETHOXYCURCUMIN manufacturers
- Product
- Demethoxycurcumin 22608-11-3
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-22
- Product
- DEMETHOXYCURCUMIN 22608-11-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- DEMETHOXYCURCUMIN 22608-11-3
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24